Protein Alignment Sirt7 and HST4

DIOPT Version :10

• Sequence 1: NP_651664.2
• Gene: Sirt7 / 43433
• FlyBaseID: FBgn0039631
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_010477.3
• Gene: HST4 / 851772
• SGDID: S000002599
• Length: 370
• Species: Saccharomyces cerevisiae
• Alignment Length: 353
• Identity: 88/353 - (24%)
• Similarity: 146/353 - (41%)
• Gaps: 103/353 - (29%)

  Fly    79 PDMVKTTKKRKERVEIYKE--RVVERE---DAPHVIEAK---VEQLANIISQA----KHLVCYTG 131
            |.:.|:.:.||.|:....|  .|.:.:   |:.|:.:::   :::.|..||.|    |.:|..:|
Yeast    36 PQLKKSVRNRKPRLSYRPELNSVFDLDAYVDSTHLSKSQRHHMDRDAGFISYALNYSKRMVVVSG 100

  Fly   132 AGISTAALIPDYRGSQGIWTLLQ--KGQDI-------GEHDLS---------------SANPTYT 172
            ||||.||.|||:|.|:||::.:.  .|:|:       |:..:|               :..||..
Yeast   101 AGISVAAGIPDFRSSEGIFSTVNGGSGKDLFDYNRVYGDESMSLKFNQLMVSLFRLSKNCQPTKF 165

  Fly   173 HMALYELHRRRLLHHVVSQNCDGL-----HLRSGLPR----NSLSEIHG---NMYVEVCKNCRPN 225
            |..|.|..|...|..:.:||.|||     ||.:.:|.    .|..::||   :|....|.|.:|
Yeast   166 HEMLNEFARDGRLLRLYTQNIDGLDTQLPHLSTNVPLAKPIPSTVQLHGSIKHMECNKCLNIKP- 229

  Fly   226 SVYWRQFDTT--EMTARYCHKTHRL--CHRCSEPLYDTIVHF-GERGNVKWPL------------ 273
                  ||..  :...::..:|..:  |.:|.|  |:|:... |.|......|
Yeast   230 ------FDPELFKCDDKFDSRTEIIPSCPQCEE--YETVRKMAGLRSTGVGKLRPRVILYNEVHP 286

  Fly   274 --NWAGATAN---AQRADVILCLGSSLKV--LKKYTWLWQMDRPARQ--------RAKICVVNLQ 323
              ::.|..||   .:|.|.::.:|:|||:  :|..         .||        |..:..:|..
Yeast   287 EGDFIGEIANNDLKKRIDCLIIVGTSLKIPGVKNI---------CRQFAAKVHANRGIVLYLNTS 342

  Fly   324 WTPKDAIASIK-----INGKCDQVMAQL 346
            ..||:.:.|:|     :.|.|..|.:.|
Yeast   343 MPPKNVLDSLKFVDLVVLGDCQHVTSLL 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt7	NP_651664.2	SIRT7	124..338	CDD:238701	71/286 (25%)
HST4	NP_010477.3	SIR2	93..362	CDD:444738	71/286 (25%)