Protein Alignment Sirt7 and SIR2

DIOPT Version :9

• Sequence 1: NP_651664.2
• Gene: Sirt7 / 43433
• FlyBaseID: FBgn0039631
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_010242.1
• Gene: SIR2 / 851520
• SGDID: S000002200
• Length: 562
• Species: Saccharomyces cerevisiae
• Alignment Length: 396
• Identity: 80/396 - (20%)
• Similarity: 135/396 - (34%)
• Gaps: 138/396 - (34%)

  Fly    20 EPKQEMDVAQSYITRAKMNPAKKDNEKRRRKDAMRRVSMILRKCDSMRT----TEDRQFLEKHPD 80
            |..|::..|.| :|..: :|..|....|..||..|.::.:|  |..:|.    |.| .|::|
Yeast   194 ERVQDLGSAIS-VTNVE-DPLAKKQTVRLIKDLQRAINKVL--CTRLRLSNFFTID-HFIQK--- 250

  Fly    81 MVKTTKKRKERVEIYKERVVEREDAPHVIEAKVEQLANIISQAKHLVCYTGAGISTAALIPDYRG 145
                                                   :..|:.::..||||:||:..|||:|.
Yeast   251 ---------------------------------------LHTARKILVLTGAGVSTSLGIPDFRS 276

  Fly   146 SQGIWTL-----LQKGQDIGEHDLSSANPT---------------YT--HMALYELHRRRLLHHV 188
            |:|.::.     |...||:..:::...:|:               |:  |..:..|..:..|...
Yeast   277 SEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRN 341

  Fly   189 VSQNCDGLHLRSGLPRNSLSEIHGNMYVEVCKNCR---PNSVYWRQFDTTEM-TARYCHKTHR-- 247
            .:||.|.|...:|:..:.|.:.||:.....|..|.   |....:.:....|: ...||:|..|
Yeast   342 YTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREY 406

  Fly   248 -----------------LCHRCSEPLY---------DTIVHFGERGNVKWPLNWAGATANAQRAD 286
                             :..|   |.|         ..|..|||....|:   ......:....|
Yeast   407 FPEGYNNKVGVAASQGSMSER---PPYILNSYGVLKPDITFFGEALPNKF---HKSIREDILECD 465

  Fly   287 VILCLGSSLKVLKKYTWLWQMDRPARQRAKICVVNL--QWTP---------KDAIASIKINGKCD 340
            :::|:|:||||           .|..:     :||:  ...|         |.|...:.:.|.||
Yeast   466 LLICIGTSLKV-----------APVSE-----IVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCD 514

  Fly   341 QVMAQL 346
            .:.|.:
Yeast   515 DIAAMV 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt7	NP_651664.2	SIRT7	124..338	CDD:238701	57/278 (21%)
SIR2	NP_010242.1	DUF592	104..261	CDD:368003	19/113 (17%)
		SIRT1	255..517	CDD:238699	60/283 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810