Protein Alignment Sirt7 and Sirt5

DIOPT Version :10

• Sequence 1: NP_651664.2
• Gene: Sirt7 / 43433
• FlyBaseID: FBgn0039631
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: XP_006517014.1
• Gene: Sirt5 / 68346
• MGIID: 1915596
• Length: 350
• Species: Mus musculus
• Alignment Length: 406
• Identity: 77/406 - (18%)
• Similarity: 129/406 - (31%)
• Gaps: 115/406 - (28%)

  Fly    37 LTDEQREIVDLTKK--FVREE-------IIPVAAHHDKTGEYPWAIIKKAWELGLTNSHIPADIG 92
            |..|.|||..|:||  ::..:       ::.|..::.|.    |:||:..       :..|..:.
Mouse   167 LNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKC----WSIIENL-------AVFPDTVT 220

  Fly    93 GTEMSIVT----SCL-VAEQFAYGCTGIMTAIEASGLGQTPVIIAGNKEQQK----KYLGRLL-- 146
            |:|.|.:.    :|: .||:.|.....:..:.|...|......|.....|||    :..||..
Mouse   221 GSEFSSLVEVRGTCVSSAEEEAENSPRMHCSAEGEWLVPIGKCICKAGYQQKGDTCEPCGRRFYK 285

  Fly   147 --EEPLVAAYCVTEPGAGSDVNGVRTRAEKKGDEYILNGQKMWITNGGVANWYFVLARTNPDPKC 209
              .:.|..:.|.|.  :.||..| .:|.|.:...|.......::            |.|.| |..
Mouse   286 SSSQDLQCSRCPTH--SFSDREG-SSRCECEDGYYRAPSDPPYV------------ACTRP-PSA 334

  Fly   210 PASKAF----TGFIVERDTPGLTPGRKE---------------------QNMGQRASDTRGITFE 249
            |.:..|    |...:|...|....||.:                     .|:|.....| |:  |
Mouse   335 PQNLIFNINQTTVSLEWSPPADNGGRNDVTYRILCKRCSWEQGECVPCGSNIGYMPQQT-GL--E 396

  Fly   250 DVRVPKENVLVGEGAGFKI--AMGTFDKTRPPVAAGAVGLA--------------QRCLDEALKY 298
            |..|...::|......|::  ..|..|.:|......||.:.              :|.|..:::.
Mouse   397 DNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAAPSQVSGVMKERVLQRSVEL 461

  Fly   299 SLERKAFGVPIAAHQAVSFMLADMAIGVETARLITMKSAWEVDQGRRNSYYASIAKCYASDIANK 363
            |.:.......:.....:.:                    :|.||..|.  |:::.....|...|.
Mouse   462 SWQEPEHPNGVITEYEIKY--------------------YEKDQRERT--YSTLKTKSTSASINN 504

  Fly   364 IATDAVQVFGGNGFNS 379
            :....|.||....|.:
Mouse   505 LKPGTVYVFQIRAFTA 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt7	NP_651664.2	SIRT7	124..338	CDD:238701	44/262 (17%)
Sirt5	XP_006517014.1	SIRT5_Af1_CobB	51..289	CDD:238703	29/132 (22%)