Protein Alignment Sirt7 and SIRT6

DIOPT Version :9

• Sequence 1: NP_651664.2
• Gene: Sirt7 / 43433
• FlyBaseID: FBgn0039631
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_057623.2
• Gene: SIRT6 / 51548
• HGNCID: 14934
• Length: 355
• Species: Homo sapiens
• Alignment Length: 362
• Identity: 116/362 - (32%)
• Similarity: 173/362 - (47%)
• Gaps: 66/362 - (18%)

  Fly   104 DAPHVIEAKVEQLANIISQAKHLVCYTGAGISTAALIPDYRGSQGIWTLLQKG-QDIGEHDLSSA 167
            |.|..:|.||.:||.::.|:..:|.:||||||||:.|||:||..|:||:.::| ....:....||
Human    25 DPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESA 89

  Fly   168 NPTYTHMALYELHRRRLLHHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVEVCKNCRPNSVYWRQF 232
            .||.|||||.:|.|..||..:||||.||||:|||.||:.|:|:||||:||.|..|:...|.....
Human    90 RPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVV 154

  Fly   233 DTTEMTARYCHKTHRLC--------HRCSEPLYDTIVHFGERGNVKWPLNW---------AGATA 280
            .|..:.|     |.|||        ..|...|.|||            |:|         |.|..
Human   155 GTMGLKA-----TGRLCTVAKARGLRACRGELRDTI------------LDWEDSLPDRDLALADE 202

  Fly   281 NAQRADVILCLGSSLKVLKKYTWLWQMDRPA--------RQRAKICVVNLQWTPKDAIASIKING 337
            .::.||:.:.||:||::           ||:        |:..::.:||||.|..|..|.::|:|
Human   203 ASRNADLSITLGTSLQI-----------RPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHG 256

  Fly   338 KCDQVMAQLMHLLHIPVPVYTKEKDPIFAHASLLMPEELHTLTQPLLKNADEEEAFTTTTEETQD 402
            ..|:||.:||..|.:.:|.:...:         ::...|..|.:|.....:.:|...|....:..
Human   257 YVDEVMTRLMKHLGLEIPAWDGPR---------VLERALPPLPRPPTPKLEPKEESPTRINGSIP 312

  Fly   403 STISSESCSFNYSDLPIG---KGPRIRTPIKNGRRVK 436
            :....|.|:.:....|..   :.|....|.:..:|||
Human   313 AGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVK 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt7	NP_651664.2	SIRT7	124..338	CDD:238701	87/239 (36%)
SIRT6	NP_057623.2	SIRT7	45..257	CDD:238701	87/239 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..355		13/66 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1503290at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820