Protein Alignment Sirt7 and SIRT7

DIOPT Version :10

• Sequence 1: NP_651664.2
• Gene: Sirt7 / 43433
• FlyBaseID: FBgn0039631
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_057622.1
• Gene: SIRT7 / 51547
• HGNCID: 14935
• Length: 400
• Species: Homo sapiens
• Alignment Length: 366
• Identity: 186/366 - (50%)
• Similarity: 247/366 - (67%)
• Gaps: 2/366 - (0%)

  Fly    27 VAQSYITRAKMNPAKKDNEKR--RRKDAMRRVSMILRKCDSMRTTEDRQFLEKHPDMVKTTKKRK 89
            :|...::|::...|::....|  ::::.:|:||.||||..:.|:.|:.:.|.:..|:|...:.|.
Human     1 MAAGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESADLVTELQGRS 65

  Fly    90 ERVEIYKERVVEREDAPHVIEAKVEQLANIISQAKHLVCYTGAGISTAALIPDYRGSQGIWTLLQ 154
            .|.|..|.|..|..|.|..:..||.:||:.:..||:||.||||||||||.||||||..|:|||||
Human    66 RRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQ 130

  Fly   155 KGQDIGEHDLSSANPTYTHMALYELHRRRLLHHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVEVC 219
            ||:.:...|||.|.||.|||::..||.::|:.||||||||||||||||||.::||:|||||:|||
Human   131 KGRSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVC 195

  Fly   220 KNCRPNSVYWRQFDTTEMTARYCHKTHRLCHRCSEPLYDTIVHFGERGNVKWPLNWAGATANAQR 284
            .:|.||..|.|.||.||.||.:.|:|.|.||:|...|.||||||||||.:..||||..||..|.|
Human   196 TSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASR 260

  Fly   285 ADVILCLGSSLKVLKKYTWLWQMDRPARQRAKICVVNLQWTPKDAIASIKINGKCDQVMAQLMHL 349
            ||.||||||||||||||..||.|.:|..:|.|:.:|||||||||..|::|::||||.||..||..
Human   261 ADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAE 325

  Fly   350 LHIPVPVYTKEKDPIFAHASLLMPEELHTLTQPLLKNADEE 390
            |.:.:|.|::.:||||:.|:.|...|..:.::..|..:.||
Human   326 LGLEIPAYSRWQDPIFSLATPLRAGEEGSHSRKSLCRSREE 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt7	NP_651664.2	SIRT7	124..338	CDD:238701	136/213 (64%)
SIRT7	NP_057622.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		4/25 (16%)
		DUF5401	<10..>86	CDD:375164	22/75 (29%)
		SIRT7	100..314	CDD:238701	136/213 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..380		3/13 (23%)