Protein Alignment Sirt7 and Sirt2

DIOPT Version :10

• Sequence 1: NP_651664.2
• Gene: Sirt7 / 43433
• FlyBaseID: FBgn0039631
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001386559.1
• Gene: Sirt2 / 361532
• RGDID: 621481
• Length: 388
• Species: Rattus norvegicus
• Alignment Length: 335
• Identity: 77/335 - (22%)
• Similarity: 126/335 - (37%)
• Gaps: 97/335 - (28%)

  Fly    96 KERVVEREDAPHVIEAKVEQLANII--SQAKHLVCYTGAGISTAALIPDYRG-SQGIWTLLQK-- 155
            |||:::        |..:|.:...:  .:.:.::|..||||||:|.|||:|. |.|::..|:|
  Rat    55 KERLLD--------ELTLEGVTRYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYANLEKYH 111

  Fly   156 -----------------------------GQDIGEHDLSSANPTYTHMALYELHRRRLLHHVVSQ 191
                                         ||         ..||..|..:..|..:.||....:|
  Rat   112 LPYPEAIFEISYFKKHPEPFFALAKELYPGQ---------FKPTICHYFIRLLKEKGLLLRCYTQ 167

  Fly   192 NCDGLHLRSGLPRNSLSEIHGNMYVEVCKNCRPNSVY---W-RQFDTTEMTARYCHKTHRLCHRC 252
            |.|.|...:||....|.|.||..|...|.|......|   | ::...:|.|.:        |.:|
  Rat   168 NIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCGKEYTMSWMKEKIFSEATPK--------CEKC 224

  Fly   253 SEPLYDTIVHFGERGNVKWPLNWAGATANAQRADVILCLGSSLKVLKKYTWLWQMDRPARQRAKI 317
            ...:...||.|||  |:. |..::...::..:.|:::.:|:||:| :.:..|......|..|
  Rat   225 QNVVKPDIVFFGE--NLP-PRFFSCMQSDFSKVDLLIIMGTSLQV-QPFASLISKAPLATPR--- 282

  Fly   318 CVVN--------------------LQWTPKDAIASIKINGKCDQVMAQLMHLLHIPVPVYTKEKD 362
            .::|                    :.:..|.|...:...|.|||....|..||.     :.||.:
  Rat   283 LLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADLLG-----WKKELE 342

  Fly   363 PIF--AHASL 370
            .:.  .||::
  Rat   343 DLVRREHANI 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt7	NP_651664.2	SIRT7	124..338	CDD:238701	61/269 (23%)
Sirt2	NP_001386559.1	SIRT1	77..331	CDD:238699	65/277 (23%)