Protein Alignment Sirt7 and Sirt1

DIOPT Version :10

• Sequence 1: NP_651664.2
• Gene: Sirt7 / 43433
• FlyBaseID: FBgn0039631
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001401888.1
• Gene: Sirt1 / 309757
• RGDID: 1308542
• Length: 741
• Species: Rattus norvegicus
• Alignment Length: 596
• Identity: 121/596 - (20%)
• Similarity: 201/596 - (33%)
• Gaps: 200/596 - (33%)

  Fly    87 KRKERVEIYKERVVEREDAPHVIEAKVEQLANIISQAKHLVCYTGAGISTAALIPDYRGSQGIWT 151
            |||:|.:|                ..:|....::.:.|.::..||||:|.:..|||:|...||:.
  Rat   227 KRKKRKDI----------------NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYA 275

  Fly   152 LL----------QKGQDI-------------------GEHDLSSANPTYTH--MALYELHRRRLL 185
            .|          |...||                   |:.     .|:..|  :||.:...:.|.
  Rat   276 RLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQF-----QPSLCHKFIALSDKEGKLLR 335

  Fly   186 HHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVEVCKNCRPNSVYWRQFDTTEMTARYCHKTHRLCH 250
            ::  :||.|.|...:|:.|  :.:.||:.....|..|:      .:.|...:.....::....|.
  Rat   336 NY--TQNIDTLEQVAGIQR--IIQCHGSFATASCLICK------YKVDCEAVRGDIFNQVVPRCP 390

  Fly   251 RC--SEPL---YDTIVHFGERGNVKWPLNWAGATANAQRADVILCLGSSLKVLKKYTWLWQMDRP 310
            ||  .|||   ...||.|||  |:....:.| ...:....|:::.:||||||           ||
  Rat   391 RCPADEPLAIMKPEIVFFGE--NLPEQFHRA-MKYDKDEVDLLIVIGSSLKV-----------RP 441

  Fly   311 AR-------QRAKICVVNLQWTPKDAIASIKINGKCDQVMAQLMHLLHIPVPVYTK--------- 359
            ..       ......::|.:..| .....:::.|.||.::.:|.|.|.   ..|.|
  Rat   442 VALIPSSIPHEVPQILINREPLP-HLHFDVELLGDCDVIINELCHRLG---GEYAKLCCNPVKLS 502

  Fly   360 ---EKDP----IFAHASLLMPEELHTLTQPLLKNADEEEAFTTTTEETQDSTISSESCSFNYSDL 417
               ||.|    ...|.|.|.|..||.          .|::.:......|||::
  Rat   503 EITEKPPRTQKELVHLSELPPTPLHI----------SEDSSSPERTVPQDSSV------------ 545

  Fly   418 PIGKGPRIRTPIKNGRRVKTNLELRQKFKTLNGQDEEIKVEHVKTNGEVKTEKDLITLESSIKIE 482
                                       ..||..|..:.||:.:    ||...|..:. |.|.:::
  Rat   546 ---------------------------IATLVDQTIKNKVDDL----EVSEPKSCVE-EKSQEVQ 578

  Fly   483 TEVKLEKLECSDTNFQQELKLLELLPKLEPLSLKEETEETPSNGFPELPKLVAIQKTHAEC---- 543
            |...:|.:...:.:|           |....|..::.|.|            ::.:|..:|
  Rat   579 TYRNVESINVENPDF-----------KAVGSSTGDKNERT------------SVAETVRKCWPNR 620

  Fly   544 LSAVPTESRL---KPLQLPP--LVPIGAPLSTPFVEPKLVLPPASQSSSIQIKSEGDGDSSTEND 603
            |:......||   :.|.:||  .:..||.:.:...:..|      .|||....|:.....|...:
  Rat   621 LAKEQISKRLDGNQYLFVPPNRYIFHGAEVYSDSEDDAL------SSSSCGSNSDSGTCQSPSLE 679

  Fly   604 NEEEEESELAQ 614
            ...|:|||:.:
  Rat   680 EPLEDESEIEE 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt7	NP_651664.2	SIRT7	124..338	CDD:238701	57/256 (22%)
Sirt1	NP_001401888.1	SIRT1	248..483	CDD:238699	60/264 (23%)