DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt7 and Sirt6

DIOPT Version :9

Sequence 1:	NP_651664.2	Gene:	Sirt7 / 43433	FlyBaseID:	FBgn0039631	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	NP_001026819.1	Gene:	Sirt6 / 299638	RGDID:	1305216	Length:	330	Species:	Rattus norvegicus

Alignment Length:	363	Identity:	112/363 - (30%)
Similarity:	169/363 - (46%)	Gaps:	91/363 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 DAPHVIEAKVEQLANIISQAKHLVCYTGAGISTAALIPDYRGSQGIWTLLQKGQ----DIGEHDL 164
            |.|..:|.||.:||.::.|:..:|.:||||||||:.|||:||..|:||:.::|.    ||   ..
  Rat    25 DPPEELECKVWELARLMWQSSTVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDI---TF 86

  Fly   165 SSANPTYTHMALYELHRRRLLHHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVEVCKNCRPNSVYW 229
            .:|.|:.|||||.:|.|...|..:||||.||||:|||.||:.|:|:||||:||.|..|:...|..
  Rat    87 ENARPSKTHMALVQLERMGFLSFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECPKCKTQYVRD 151

  Fly   230 RQFDTTEMTARYCHKTHRLC--------HRCSEPLYDTIVHFGERGNVKWPLNWAGATAN----- 281
            ....|..:.|     |.|||        ..|...|.|||            |:|..|..:
  Rat   152 TVVGTMGLKA-----TGRLCTVAKARGLRACRGELRDTI------------LDWEDALPDRDLTL 199

  Fly   282 ----AQRADVILCLGSSLKVLKKYTWLWQMDRPA--------RQRAKICVVNLQWTPKDAIASIK 334
                ::.||:.:.||:||::           ||:        |:..::.:||||.|..|..|.:.
  Rat   200 ADEASRTADLSVTLGTSLQI-----------RPSGNLPLATKRRGGRLVIVNLQPTKHDRQADLC 253

  Fly   335 INGKCDQVMAQLMHLLHIPVPVYTKEKDPIFAHASLLMPEELHTLTQPLLKNADEEEAFTTTTEE 399
            |:|..|:||.:||..|.:.:|.:...:         ::.:.|..|.:|:...|:.......:.:.
  Rat   254 IHGYVDEVMCKLMKHLGLEIPTWDGPR---------VLEKALPPLPRPVAPKAEPPVHLNGSYKP 309

  Fly   400 TQDSTISSESCSFNYSDLPIGKGPRIRTPIKNGRRVKT 437
            ..||.:                      |.:..:||||
  Rat   310 KPDSPV----------------------PHRPPKRVKT 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt7	NP_651664.2	SIRT7	124..338	CDD:238701	85/242 (35%)
Sirt6	NP_001026819.1	SIRT7	45..257	CDD:238701	85/242 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1503290at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820