Protein Alignment Sirt7 and sir-2.1

DIOPT Version :9

• Sequence 1: NP_651664.2
• Gene: Sirt7 / 43433
• FlyBaseID: FBgn0039631
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001255484.1
• Gene: sir-2.1 / 177924
• WormBaseID: WBGene00004800
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 644
• Identity: 133/644 - (20%)
• Similarity: 219/644 - (34%)
• Gaps: 205/644 - (31%)

  Fly     1 MEKDLGEEKD---------QDQEQNTE---MEPKQEMDVAQSYITRAKMNPAKKDNEKRRRKDAM 53
            |.:|.|.:.:         :..|:|.|   |...||.|::.:        |....:..|:|.::.
 Worm     1 MSRDSGNDSEVAVTHGEVQEITEENPEIGSMHITQETDISDA--------PETNTDSSRQRTEST 57

  Fly    54 RRVSMILRKCDSMRTTEDRQFLEKHPDMVKTTKKRKERV------------EIYKE----RVVER 102
            ..||           :|..|    :.|.:.:..:|.:|:            :|:.:    |:...
 Worm    58 TSVS-----------SESWQ----NNDEMMSNLRRAQRLLDDGATPLQIIQQIFPDFNASRIATM 107

  Fly   103 EDAPH------VIE-AKVEQ-LANIISQA---------KHLVCYTGAGISTAALIPDYRGSQGIW 150
            .:..|      ::| |.|.| |.|..|.|         ||::..||||:|.:..|||:|...||:
 Worm   108 SENAHFAILSDLLERAPVRQKLTNYNSLADAVELFKTKKHILVLTGAGVSVSCGIPDFRSKDGIY 172

  Fly   151 TLLQK---------------------------------GQDIGEHDLSSANPTYTHMALYELHRR 182
            ..|:.                                 ||.:         |:.:|..:.||...
 Worm   173 ARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFPGQFV---------PSVSHRFIKELETS 228

  Fly   183 RLLHHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVEVCKNCRPNSVYWRQFDTTE-----MTARYC 242
            ..|....:||.|.|..::|:.|  :.|.||:.....|..|      .:::|..|     :..|..
 Worm   229 GRLLRNYTQNIDTLEHQTGIKR--VVECHGSFSKCTCTRC------GQKYDGNEIREEVLAMRVA 285

  Fly   243 HKTHRLCHRCSEPLYDTIVHFGERGNVKWPLNWAGATANAQRADVILCLGSSLKVLKKYTWLWQM 307
            |     |.||...:...||.|||....::..:   .|.:..:.|:|:.:||||||
 Worm   286 H-----CKRCEGVIKPNIVFFGEDLGREFHQH---VTEDKHKVDLIVVIGSSLKV---------- 332

  Fly   308 DRPARQRAKI--CV--------VNLQWTPKDAIASIKINGKCDQVMAQLMHLLHIPVPVYTKEKD 362
             ||.   |.|  ||        :|.:..| ...|.|::.|.||.::..:...|...........|
 Worm   333 -RPV---ALIPHCVDKNVPQILINRESLP-HYNADIELLGNCDDIIRDICFSLGGSFTELITSYD 392

  Fly   363 PIFAHASLLMPEELHTLTQPLLKN----ADEEEAFTTTTEETQDSTISSESCSFNYSDLPIGKGP 423
            .|       |.::..|.:|...:|    ..:|:......:|.::.         :.||.|..|.|
 Worm   393 SI-------MEQQGKTKSQKPSQNKRQLISQEDFLNICMKEKRND---------DSSDEPTLKKP 441

  Fly   424 RIRTPIKNGRRVKTNLELRQKFK------TLNGQDEEIKVEH----------------------- 459
            |:.....:....|.|.:..||.|      |.|..|...|::|
 Worm   442 RMSVADDSMDSEKNNFQEIQKHKSEDDDDTRNSDDILKKIKHPRLLSITEMLHDNKCVAISAHQT 506

  Fly   460 VKTNGEVKTEKDLITLESSIKIETEVKLEKLECSDTNFQQELKLLELLPKLEPLSLKEE 518
            |....|...:.:.:.|...:..||..:........:|...|...|.....|:...|.:|
 Worm   507 VFPGAECSFDLETLKLVRDVHHETHCESSCGSSCSSNADSEANQLSRAQSLDDFVLSDE 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt7	NP_651664.2	SIRT7	124..338	CDD:238701	63/261 (24%)
sir-2.1	NP_001255484.1	SIRT1	146..376	CDD:238699	66/269 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910