DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sirt7 and Sirt6

DIOPT Version :10

Sequence 1:NP_651664.2 Gene:Sirt7 / 43433 FlyBaseID:FBgn0039631 Length:771 Species:Drosophila melanogaster
Sequence 2:XP_321669.4 Gene:Sirt6 / 1281717 VectorBaseID:AGAMI1_004224 Length:354 Species:Anopheles gambiae


Alignment Length:391 Identity:123/391 - (31%)
Similarity:177/391 - (45%) Gaps:87/391 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    99 VVEREDAPHVIEAKVEQLANIISQAKHLVCYTGAGISTAALIPDYRGSQGIWTLLQKGQDIGEH- 162
            |.|..|.|.::|.|.|||..::..:.|.|.:|||||||:|.|||:||..|:|||.:||:....: 
Mosquito    20 VAEIFDTPELVEEKCEQLVKMMLASSHTVVHTGAGISTSAGIPDFRGPNGVWTLEEKGEKPAVNI 84

  Fly   163 DLSSANPTYTHMALYELHRRRLLHHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVEVCKNCRPNSV 227
            ....|.||.|||||..|.....:.::||||.|||||||||.|..|||:||||::|||..||...|
Mosquito    85 SFDDAVPTRTHMALKSLVASGHVQYIVSQNIDGLHLRSGLAREHLSELHGNMFLEVCTKCRRQYV 149

  Fly   228 YWRQFDTT--EMTARYCHKT--HRLCHRCSEPLYDTIVHFGERGNVKWPLNWAG---------AT 279
            ......|.  :.|...|..|  .|.|.|  ..|.|.|            |:|..         |.
Mosquito   150 RSSPAPTVGKKETGNICPGTSAERACRR--GKLIDNI------------LDWEHDLPENDLQLAF 200

  Fly   280 ANAQRADVILCLGSSLKVLKKYTWLWQMDRPARQ-----RAKICVVNLQWTPKDAIASIKINGKC 339
            .::..||:.:|||::|:::.      ..|.|.:.     |..||  |||.|..|..|.:||:...
Mosquito   201 MHSAMADLNICLGTTLQIVP------SGDLPLKNLKHGGRLVIC--NLQPTKHDKKADLKISTYV 257

  Fly   340 DQVMAQLMHLLHIPVPVYTKEKDPIFAHASLLMPEELHTLTQPLLKNADEEEAFTTTTEETQDST 404
            |.|:.::...|.:.:|.|.:|:||....            |..:..|.|.:  ...:.|:..|||
Mosquito   258 DAVLERVAKRLGVEIPEYRREEDPTKRD------------TYSVQWNIDGK--MVKSLEKRYDST 308

  Fly   405 ISSESCSFNYSDLPIGKGPRIRTPIKNGRRVKTNLELRQKFKTLNGQDEEIKVEHVKTNGEVKTE 469
            |                            :.||.|:.|....:::...|::|    :.|.::|.|
Mosquito   309 I----------------------------KEKTQLKKRCSTSSIDQDREDLK----RNNKKLKQE 341

  Fly   470 K 470
            :
Mosquito   342 Q 342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sirt7NP_651664.2 SIRT7 124..338 CDD:238701 89/232 (38%)
Sirt6XP_321669.4 None

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