Protein Alignment CG11843 and PLAT

DIOPT Version :10

• Sequence 1: NP_651663.1
• Gene: CG11843 / 43432
• FlyBaseID: FBgn0039630
• Length: 316
• Species: Drosophila melanogaster
• Sequence 2: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Alignment Length: 338
• Identity: 91/338 - (26%)
• Similarity: 124/338 - (36%)
• Gaps: 129/338 - (38%)

  Fly    27 VGSCS-----RYKKSVFEERIEFGFLLPGASIESRIIDNCRSYTPLIVGGHPAQPREFPHMARLG 86
            |.|||     :|.:..|  ||:.|.....||                   ||.|...|..
Human   293 VPSCSTCGLRQYSQPQF--RIKGGLFADIAS-------------------HPWQAAIFAK----- 331

  Fly    87 RRPDPSSRADWFCGGVLISERFVLTAAHCLESER----------GEVNVVRLGELDFDSLDEDAA 141
            .|..|..|  :.|||:|||..::|:||||.: ||          |....|..||.:
Human   332 HRRSPGER--FLCGGILISSCWILSAAHCFQ-ERFPPHHLTVILGRTYRVVPGEEE--------- 384

  Fly   142 PRDYMVAGYIAHPGYEDPQFYHDIGLVKL-----------------------------TEAVVFD 177
             :.:.|..||.|..::|..:.:||.|::|                             ||..:..
Human   385 -QKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSG 448

  Fly   178 LYKHPACLPFQDERSSDSFIAVGWGSTGLALKPSAQLLKVKLQRYGNWVCKKLLTRQVEEFPRGF 242
            ..||.|..||..||..::.:         .|.||::.           ..:.||.|.|.:
Human   449 YGKHEALSPFYSERLKEAHV---------RLYPSSRC-----------TSQHLLNRTVTD----- 488

  Fly   243 DGNNQLCVGSEMA-------QDTCNGDSGGPLLMYHREYPCM----YVVVGITSAGLSCGSPGIP 296
               |.||.|...:       .|.|.|||||||:       |:    ..:|||.|.||.||...:|
Human   489 ---NMLCAGDTRSGGPQANLHDACQGDSGGPLV-------CLNDGRMTLVGIISWGLGCGQKDVP 543

  Fly   297 GIYTRVYPYLGWI 309
            |:||:|..||.||
Human   544 GVYTKVTNYLDWI 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11843	NP_651663.1	Tryp_SPc	68..312	CDD:238113	80/292 (27%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		EGF	86..117	CDD:394967
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:395005	1/2 (50%)
		Tryp_SPc	313..559	CDD:238113	83/316 (26%)