DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11843 and Prss12

DIOPT Version :9

Sequence 1:	NP_001287578.1	Gene:	CG11843 / 43432	FlyBaseID:	FBgn0039630	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_032965.1	Gene:	Prss12 / 19142	MGIID:	1100881	Length:	761	Species:	Mus musculus

Alignment Length:	260	Identity:	87/260 - (33%)
Similarity:	122/260 - (46%)	Gaps:	39/260 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 IVGGHPAQPREFPHMARLGRRPDPSSRAD--WFCGGVLISERFVLTAAHCLE--SERGEVNVVRL 128
            |:||:.:....:|..|.|..|   |:..|  ..||..|:|..:|||||||.:  ........||:
Mouse   517 IIGGNNSLRGAWPWQASLRLR---SAHGDGRLLCGATLLSSCWVLTAAHCFKRYGNNSRSYAVRV 578

  Fly   129 GELDFDSLDEDAAPRDYMVAGYIAHPGYEDPQFYHDIGLVKL----TEAVVFDLYKHPACLPFQD 189
            |  |:.:|..:...::..|...:.|..|...:..:||.||:|    .:......:..|||||...
Mouse   579 G--DYHTLVPEEFEQEIGVQQIVIHRNYRPDRSDYDIALVRLQGPGEQCARLSTHVLPACLPLWR 641

  Fly   190 ER----SSDSFIAVGWGSTGLALKPSAQLLKVKL--QRYGNWVCKKLLTRQVEEFPRGFDGNNQL 248
            ||    :|:..| .|||.||.|...:.|...|.|  :|:    ||       |.:...|.| ..|
Mouse   642 ERPQKTASNCHI-TGWGDTGRAYSRTLQQAAVPLLPKRF----CK-------ERYKGLFTG-RML 693

  Fly   249 CVGS---EMAQDTCNGDSGGPLLMYHREYPC-MYVVVGITSAGLSCGSPGIPGIYTRVYPYLGWI 309
            |.|:   :...|:|.|||||||:.   |.|. .:||.|:||.|..||....||:||||..::.||
Mouse   694 CAGNLQEDNRVDSCQGDSGGPLMC---EKPDESWVVYGVTSWGYGCGVKDTPGVYTRVPAFVPWI 755

Fly 310 309
Mouse 756 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11843	NP_001287578.1	Tryp_SPc	68..312	CDD:238113	87/260 (33%)
CG11843	NP_001287578.1	Tryp_SPc	68..309	CDD:214473	85/258 (33%)
Prss12	NP_032965.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..87
		KR	83..159	CDD:214527
		SR	166..265	CDD:214555
		SRCR	171..265	CDD:278931
		SR	273..372	CDD:214555
		SRCR	278..371	CDD:278931
		SR	386..485	CDD:214555
		SRCR	396..485	CDD:278931
		Zymogen activation region	505..516
		Tryp_SPc	516..755	CDD:214473	85/258 (33%)
		Tryp_SPc	517..758	CDD:238113	87/260 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960