DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11843 and Plat

DIOPT Version :9

Sequence 1:	NP_001287578.1	Gene:	CG11843 / 43432	FlyBaseID:	FBgn0039630	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_032898.2	Gene:	Plat / 18791	MGIID:	97610	Length:	559	Species:	Mus musculus

Alignment Length:	338	Identity:	89/338 - (26%)
Similarity:	127/338 - (37%)	Gaps:	125/338 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DMDVVGSCS--RYKKSVFEERIEFGFLLPGASIESRIIDNCRSYTPLIVGGHPAQPREFPHMARL 85
            ||....:|.  :||:..|  ||:.|.                 ||.  :..||.|...|     :
Mouse   290 DMSPCSTCGLRQYKRPQF--RIKGGL-----------------YTD--ITSHPWQAAIF-----V 328

  Fly    86 GRRPDPSSRADWFCGGVLISERFVLTAAHCLESERGEVNVVRL----------GELDFDSLDEDA 140
            ..:..|..|  :.|||||||..:||:||||. .||...|.:::          ||.:
Mouse   329 KNKRSPGER--FLCGGVLISSCWVLSAAHCF-LERFPPNHLKVVLGRTYRVVPGEEE-------- 382

  Fly   141 APRDYMVAGYIAHPGYEDPQFYHDIGLVKL-----------------------------TEAVVF 176
              :.:.:..||.|..::|..:.:||.|::|                             ||..:.
Mouse   383 --QTFEIEKYIVHEEFDDDTYDNDIALLQLRSQSKQCAQESSSVGTACLPDPNLQLPDWTECELS 445

  Fly   177 DLYKHPACLPFQDERSSDSFIAVGWGSTGLALKPSAQLLKVKLQRYGNWVCKKLLTRQVEEFPRG 241
            ...||.|..||..:|..::.:         .|.||::.....|       ..|.:|
Mouse   446 GYGKHEASSPFFSDRLKEAHV---------RLYPSSRCTSQHL-------FNKTVT--------- 485

  Fly   242 FDGNNQLCV------GSEMAQDTCNGDSGGPLLMYHREYPCM----YVVVGITSAGLSCGSPGIP 296
               ||.||.      |::...|.|.|||||||:       ||    ..:.||.|.||.||...:|
Mouse   486 ---NNMLCAGDTRSGGNQDLHDACQGDSGGPLV-------CMINKQMTLTGIISWGLGCGQKDVP 540

  Fly   297 GIYTRVYPYLGWI 309
            |:||:|..||.||
Mouse   541 GVYTKVTNYLDWI 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11843	NP_001287578.1	Tryp_SPc	68..312	CDD:238113	78/291 (27%)
CG11843	NP_001287578.1	Tryp_SPc	68..309	CDD:214473	76/289 (26%)
Plat	NP_032898.2	FN1	38..80	CDD:214494
		Important for binding to annexin A2. /evidence=ECO:0000250	39..49
		EGF	83..115	CDD:394967
		Kringle	124..205	CDD:395005
		KR	210..295	CDD:238056	2/4 (50%)
		Tryp_SPc	311..556	CDD:238113	81/315 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960