Protein Alignment CG11841 and PLAT

DIOPT Version :10

• Sequence 1: NP_651661.1
• Gene: CG11841 / 43430
• FlyBaseID: FBgn0039628
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 90/331 - (27%)
• Similarity: 139/331 - (41%)
• Gaps: 78/331 - (23%)

  Fly    24 QNPDPFAQLAC--TKFKQIVFEERVAISFFFTDAPITYETVDSC---HGSRP--LIVDGTPAEPK 81
            :|||..|:..|  .|.:::.:|        :.|.|    :..:|   ..|:|  .|..|..|:..
Human   268 RNPDGDAKPWCHVLKNRRLTWE--------YCDVP----SCSTCGLRQYSQPQFRIKGGLFADIA 320

  Fly    82 EFPFAARL--GHRKTNNEIKWFCGGTLISNRLVLTAAHCF---FSEH------GEVNVVRLGELE 135
            ..|:.|.:  .||::..| ::.|||.|||:..:|:|||||   |..|      |....|..||
Human   321 SHPWQAAIFAKHRRSPGE-RFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGE-- 382

  Fly   136 FDTDTDDAEPEDFGVLALKAHPGFENPQLYNDIGIVQL----DREVKFNRYKHPACLP-----FD 191
                    |.:.|.|.....|..|::....|||.::||    .|..:.:......|||     ..
Human   383 --------EEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLP 439

  Fly   192 DGEQHESFIAIGWGQ-KKFAQKESKKLLKVQLQGY-KDRCVSSVDANDELPNGYEPKSQLCIGSR 254
            |..:.|   ..|:|: :..:...|::|.:..::.| ..||.|     ..|.|.....:.||.|..
Human   440 DWTECE---LSGYGKHEALSPFYSERLKEAHVRLYPSSRCTS-----QHLLNRTVTDNMLCAGDT 496

  Fly   255 DN-------KDTCNGDSGGPVLAYHKDLACM----YHVMGITSAGITCSTPDIPSAYTRVHYFLN 308
            .:       .|.|.||||||       |.|:    ..::||.|.|:.|...|:|..||:|..:|:
Human   497 RSGGPQANLHDACQGDSGGP-------LVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLD 554

  Fly   309 WIKGEL 314
            ||:..:
Human   555 WIRDNM 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11841	NP_651661.1	Tryp_SPc	72..311	CDD:238113	77/271 (28%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		EGF	86..117	CDD:394967
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:395005	9/39 (23%)
		Tryp_SPc	313..559	CDD:238113	77/271 (28%)