Protein Alignment MOV10 and ECM32

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_011103.1
• Gene: ECM32 / 856923
• SGDID: S000000978
• Length: 1121
• Species: Saccharomyces cerevisiae
• Alignment Length: 654
• Identity: 158/654 - (24%)
• Similarity: 271/654 - (41%)
• Gaps: 169/654 - (25%)

Human   376 LLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFVHKVELDRVKLSFSMSLLSRFVDG 440
            ||.|..|...|.:|      ..|.     |..|..:.|. |:.::.:.|.|....:.|
Yeast   537 LLALGRPAFNERQP------FFFC-----TQDEQKVWYI-FIKELSIQRGKYVLLVEL------- 582

Human   441 LTFKVNFTFNRQPLRVQHRALEL--------TGRWLLWPMLFPVAPRDVPLLPSDVKLK--LYDR 495
                  |::|...|..::.:.:.        |.| :|:.|.....|:.:.||.....:|  .:|.
Yeast   583 ------FSWNNLSLPTKNGSSQFKLLPTSAQTSR-ILFAMTRITNPKFIDLLLGQKPIKEIYFDN 640

Human   496 SLESNPEQLQ-----AMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAP 555
            .|:.:.::|.     |:.|::..:..    |:.||||||||.|:.|.|.||::......||..|.
Yeast   641 RLKFSSDKLNRSQKTAVEHVLNNSIT----ILQGPPGTGKTSTIEEIIIQVIERFHAFPILCVAA 701

Human   556 SNSGADLLCQRLRVHLPS-SIYRLLAPSRD------------------IRMVPEDIKPCCNWDAK 601
            ||...|.:.:::..:.|. .|.|:|:..::                  .:.:..|::...| ..:
Yeast   702 SNIAIDNIAEKIMENRPQIKILRILSKKKEQQYSDDHPLGEICLHNIVYKNLSPDMQVVAN-KTR 765

Human   602 KGEYVFPAK-------------KKLQEYRVLITTLITAG---RLVSAQFPIDHFTHIFIDEAGHC 650
            :||.:..::             |.:.:.:::.||.|.||   ..|..:.|:     :.:|||...
Yeast   766 RGEMISKSEDTKFYKEKNRVTNKVVSQSQIIFTTNIAAGGRELKVIKECPV-----VIMDEATQS 825

Human   651 MEPESLVAIAGLMEVKETGDPG-GQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYK 714
            .|..:||.::         .|| ...|..||.:||......|     .|..||.||:|: |..|
Yeast   826 SEASTLVPLS---------LPGIRNFVFVGDEKQLSSFSNIP-----QLETSLFERVLS-NGTY- 874

Human   715 KGPDGYDPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFH 779
            |.|...|.|        ||.||.|.:.|.:..|.|||:  ..|.|.::  .|.|:..   |:.|:
Yeast   875 KNPLMLDTQ--------YRMHPKISEFPIKKIYNGELK--DGVTDEQK--AWPGVQH---PLFFY 924

Human   780 GV-MGKDEREGNSP------SFFNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQV 837
            .. :|.:.|..::.      ::.|..|...:...:::|:...      ::....:|||:||..|.
Yeast   925 QCDLGPESRVRSTQRDIVGFTYENKHECVEIVKIIQILMLDK------KVPLEEIGVITPYSAQR 983

Human   838 EKIRYCITK----------LDREL-----------RG---------LDDIKDLKVGSVEEFQGQE 872
            :.:...:||          :.:|.           :|         ::.|..|.|.:|:.|||.|
Yeast   984 DLLSDILTKNVVINPKQISMQQEYDEIELFNAAGSQGTAGSLQNNVINIINGLHVATVDSFQGHE 1048

Human   873 RSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNP-LLLGHDPDWKVFLE 936
            :|.|:.|.||:       :.:..:|||::.:|.|||:||||..||:|||. :|...||.||.::.
Yeast  1049 KSFIIFSCVRN-------NTENKIGFLRDKRRLNVALTRAKHGLIVVGNKNVLRKGDPLWKDYIT 1106

Human   937 FCKE 940
            :.:|
Yeast  1107 YLEE 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	65/275 (24%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	63/242 (26%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965		7/21 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003
ECM32	NP_011103.1	TIGR00376	612..1114	CDD:273041	139/553 (25%)
		AAA_12	860..1092	CDD:463780	72/261 (28%)