Protein Alignment MOV10 and mov10b.1

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_001037807.2
• Gene: mov10b.1 / 556024
• ZFINID: ZDB-GENE-030131-9089
• Length: 1013
• Species: Danio rerio
• Alignment Length: 1049
• Identity: 448/1049 - (42%)
• Similarity: 629/1049 - (59%)
• Gaps: 94/1049 - (8%)

Human     4 KFSCRQLREAGQCFESFLVVRGLDMETDRERLRTIYNRDFKISFGTPAPGFSSMLYGMKIANLAY 68
            |.|...:|..|..|..||..|.....|||..|:.|||..|:...|...|.|||:|:.:..::...
Zfish     8 KLSRDDIRAVGFDFIEFLDDRETRSTTDRNTLKEIYNEQFRDRDGVRDPNFSSVLFALTRSSRTR 72

Human    69 VTKT------RVRFFRLDRW------------------------------ADVRFPEKR---RMK 94
            ||::      ::|..:.|:|                              :.|..||.|   |.:
Zfish    73 VTRSEVFFDKKIRVRQNDQWSRPYRSQQNHATPHLNDAISRPSTTRVSDPSSVPEPENRVIARRR 137

Human    95 LGSDISKHHKSLLAKIFYDRAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGG 159
            |...|.:...|      .|.:.:...|:|  |.|....:..||::...::......|.|.:.|.|
Zfish   138 LAKTIMRQGNS------EDMSVFFADKYG--VRVSSELQIEDGKIHWCVEGAEVHELKLFVENTG 194

Human   160 TQSVTLTHLFPLCRTPQFAFYNEDQEL----PCPLGPGECYELHVHCKTSFVGYFPATVLWELLG 220
            .:::..| .|......|:...::.|.:    |..|.|.|.||:.:..|:..:|.:|||:.:|.
Zfish   195 QEAILFT-CFSALHYLQYFTLDDSQRVRKDNPHRLEPNETYEVILRFKSDQIGVYPATLAFEF-- 256

Human   221 PGESGSEGAGTFYIARFLAAVAHSPLAAQLKPMTPFKRTRITGNPVVTNRIEEGERPDRAKGYDL 285
               ..::....|:|.||:.|...|.|.|||.|..||:..|:..|..:...|:||.:|:.:....|
Zfish   257 ---KENQDTRPFHIVRFIEAQHRSELTAQLGPTEPFRPKRLDTNQPMKWSIDEGFKPESSSQNFL 318

Human   286 ELSMALGTYYPPPRLRQLLPMLLQGTSIFTAPKEIAEIKAQLETALKWRNYEVKLRLLLHLEELQ 350
            :..:.|..|..|.....|:.:|....|   :.|::.|.:..||:.|.:.||..:..|||:|||.|
Zfish   319 KFVVPLDNYNCPSYTSALIEVLKGNRS---SGKQLQEHQLTLESDLSFNNYMDRFDLLLYLEEDQ 380

Human   351 MEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKG 415
            |..||:.|:.:.|.|.   .|::.:||.||:|||:|:||||||||||....|.|....:...|||
Zfish   381 MRMDIKRYNKKDVSMV---RDRDKKLLVLELPGVSENRPSVLRGDHLLLTKSEELQNSNVTKYKG 442

Human   416 FVHKVELDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWPMLFPVAPRD 480
            :||:||||:|||.||..||.||:|.:.|.|.||.||.|||:||||:.:..:..|..:|||||.|.
Zfish   443 YVHRVELDQVKLGFSKRLLERFIDNMKFSVEFTINRLPLRLQHRAVHMVVQHHLKDVLFPVASRR 507

Human   481 V-PLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKH 544
            : |:.||  .|:|:|:.||.||||..|:.:||.||::||||::|||||||||||:|||||||.|:
Zfish   508 LNPVSPS--ALRLFDQKLEKNPEQKTAVCNIVAGTSKPAPYLVFGPPGTGKTVTIVEAIKQVEKN 570

Human   545 LPKAHILACAPSNSGADLLCQRL--RVHLPS-SIYRLLAPSRDIRMVPEDIKPCCNWDAKKGEYV 606
            ...|.|||||||||.||.|.::|  ..|:.: :|||:.|.||:.:.:|:.::...|.:.:  ..:
Zfish   571 TGGARILACAPSNSAADQLGEKLITSQHVDARNIYRIYASSRNPKEIPKVLENNSNVEGE--NII 633

Human   607 FPAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDP 671
            ||.|:.|..|::::.||:|||||||..||:.||:|||:|||||.:|||.::::|||:.. ||
Zfish   634 FPCKEDLMPYKIVVCTLVTAGRLVSGGFPVGHFSHIFVDEAGHAVEPEIVISVAGLLNA-ET--- 694

Human   672 GGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRSHP 736
             |||||||||:||||:||||...|:|||.||||||:|.|.||:||..|:|.:::||||:||||||
Zfish   695 -GQLVLAGDPKQLGPILRSPFAIKYGLGLSLLERLMTQNELYQKGDTGFDNRYVTKLLQNYRSHP 758

Human   737 TILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAA 801
            :||.:||:|:|:.||:||||.:...::|.|..||::|||:|||||:||||||..||||||..|..
Zfish   759 SILKVPNELFYDNELKACADEISSRQYCTWEHLPKRGFPVIFHGVVGKDERESTSPSFFNTSEID 823

Human   802 TVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVE 866
            .:..|||.||...:|||.|::||:.:|:|:||||||||||..| |:.|||:.|..|::|||||||
Zfish   824 KIMDYLKKLLLTQAKKGIAKISPKDIGIIAPYRKQVEKIRQAI-KIHRELKSLSGIEELKVGSVE 887

Human   867 EFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDW 931
            |||||||.||::||||||:..:.||..||:|||||.|||||||||||||||:||||::|..|..|
Zfish   888 EFQGQERKVIIVSTVRSSKEHIILDDKFNIGFLKNEKRFNVAVTRAKALLIMVGNPIILRTDEIW 952

Human   932 KVFLEFCKENGGYTGCPFPAKLDLQQGQNLLQGLSKLSPSTSGPHSHDYLPQE--REGEGGLSLQ 994
            ..|:.:|.:..||||...   ..|::...:.:.|..|:           :.||  .|.|..:..|
Zfish   953 GRFMNYCIQERGYTGYDI---THLEETDVIAERLLSLN-----------IRQEITVETEESVVQQ 1003

Human   995 -VEPEWRNE 1002
             :.|.||:|
Zfish  1004 FLSPPWRHE 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	130/237 (55%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	124/204 (61%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965		12/43 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003		10/40 (25%)
mov10b.1	NP_001037807.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..129		2/37 (5%)
		DEXXQc_Helz-like	524..755	CDD:350796	130/237 (55%)
		DEAG box	672..675		2/2 (100%)
		SF1_C_Upf1	756..960	CDD:350195	124/204 (61%)