Protein Alignment MOV10 and Mov10

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_611185.3
• Gene: Mov10 / 36922
• FlyBaseID: FBgn0034187
• Length: 764
• Species: Drosophila melanogaster
• Alignment Length: 783
• Identity: 245/783 - (31%)
• Similarity: 361/783 - (46%)
• Gaps: 150/783 - (19%)

Human   294 YYPPPRLRQLLPM-----LLQGTSIF-----TAPKEIAEIKAQLETAL---KWRNYEVKLRLLLH 345
            ||||.  .:::..     |....|:|     |...|...:.:.::|.|   ...|.|      |:
  Fly     6 YYPPS--NEMIEANTNQDLSANNSVFGDFMKTKRLEFYNVCSVMQTLLTIDDLSNME------LY 62

Human   346 LEELQMEHDIRHYDLESVPMTWDPVDQN------PRLLTLEVPGVTESRPSVLRGDHLFALLSSE 404
            .:.:|.:..::.....:..:|:.....|      |.|..:.:........|.|....:.||| ..
  Fly    63 AQLIQSDVPVQRVSKLTYKITFKSTPVNAEDFVAPNLDQVVLVPKASLLASPLPKQLVLALL-PH 126

Human   405 THQE----DP-ITYKGFVHKVELDRVKLSFS---MSLLSRFVDGLTFKVNFTFNRQPLRVQHRAL 461
            .|::    || :.:...|.||....|.:.||   .::||    |..|.......|..:|..:|||
  Fly   127 PHEDLEPGDPMLRHVASVDKVSSTTVHVRFSRKHKAVLS----GQRFYAIIRSRRLTIRYMYRAL 187

Human   462 E------LTGRWLL----W------------------PMLFPVAPRDVPLLPSDVKLKLYDRSLE 498
            .      |..|:|.    |                  |......|:: |..|:  .|.|.:.::.
  Fly   188 NLLQESPLVRRYLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQE-PATPT--SLSLLNSTIY 249

Human   499 SNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADL- 562
            ||.|||:|::.||.|.:...|||:|||||||||.|:||||.|:....|::.||..|.|||..|.
  Fly   250 SNAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIVEAILQLRLQQPQSRILVTAGSNSACDTI 314

Human   563 ---LCQ------RLRVH-----LPSSIYRLL-APSRDI-----RMVPEDIKPCCNWDAKKGEYVF 607
               ||:      ||:.|     ||...::|: ..||.|     ..||..:..  |.:..|..|..
  Fly   315 ALKLCEYIESNIRLQEHFAQQKLPEPDHQLIRVYSRSIYEKGFASVPSLLLK--NSNCSKSIYDH 377

Human   608 PAKKKLQEYRVLITTLITAGRLVSAQF-PIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDP 671
            ....::.:|.:::.||.|..|||:... ..:.||||||||||...|||:|:   |:|.:|:|.|
  Fly   378 IKASRIVKYGIIVATLCTVARLVTDTLGRYNFFTHIFIDEAGASTEPEALI---GIMGIKQTAD- 438

Human   672 GGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDG-YDPQFITKLLRNYRSH 735
             ..::|:||.:|||.|::|......||..||:|||| .:..||...:| ||.....:|.||||||
  Fly   439 -CHVILSGDHKQLGAVIKSNRAASLGLSRSLMERLL-QSDCYKSDENGNYDRNRQMRLCRNYRSH 501

Human   736 PTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEA 800
            |.|:.:.|:|||.|||:|.|..:|......|:.|....|||||....|...||.||.|.:|..||
  Fly   502 PQIVRLFNELYYNGELKAQAPAMDVNLAANWSVLTNPQFPIIFQATHGVTNREQNSTSSYNNLEA 566

Human   801 ATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSV 865
            ..:..|:|.|:      ....:....||:::||..|.:    .:||| .:.:|..::   :||||
  Fly   567 EVICWYVKRLI------NDRVVGQEDVGIVAPYTAQGK----LVTKL-LQSKGYPNV---EVGSV 617

Human   866 EEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPD 930
            |.:||:|:::|:.|.|:|..         |:||:.||:|.||.::|||||||:||||:.|.|..|
  Fly   618 ETYQGREKTIIIASLVKSFT---------NMGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSD 673

Human   931 WKVFLEFCKENGGYTGCPFPAKLDLQQGQNLLQGLSKLSPSTSGPHSHDYLPQEREGEGGLSLQV 995
            :|..:..||::|.|.                      |....||...|..:..:...|...|
  Fly   674 FKFVINECKKHGTYL----------------------LKKRDSGQRPHILIKADESNEESSS--- 713

Human   996 EPE 998
            |||
  Fly   714 EPE 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	101/257 (39%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	77/204 (38%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965		10/43 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003		9/33 (27%)
Mov10	NP_611185.3	DEXXQc_Helz-like	251..499	CDD:350796	100/255 (39%)
		DNA2	<388..684	CDD:440729	130/324 (40%)