Protein Alignment MOV10 and Mov10

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_001101181.1
• Gene: Mov10 / 310756
• RGDID: 1598327
• Length: 1004
• Species: Rattus norvegicus
• Alignment Length: 1004
• Identity: 919/1004 - (91%)
• Similarity: 953/1004 - (94%)
• Gaps: 1/1004 - (0%)

Human     1 MPSKFSCRQLREAGQCFESFLVVRGLDMETDRERLRTIYNRDFKISFGTPAPGFSSMLYGMKIAN 65
            ||||||||:|||.||.|||||..||||:||||||||.|||||||.|:||||||||||||||||||
  Rat     1 MPSKFSCRKLRETGQGFESFLAERGLDLETDRERLRAIYNRDFKPSYGTPAPGFSSMLYGMKIAN 65

Human    66 LAYVTKTRVRFFRLDRWADVRFPEKRRMKLGSDISKHHKSLLAKIFYDRAEYLHGKHGVDVEVQG 130
            ||:|||||||||:|||||||:.|||||:|.||.|||.|:||||:||:||||||||||||||||||
  Rat    66 LAFVTKTRVRFFKLDRWADVQLPEKRRIKPGSSISKQHRSLLARIFHDRAEYLHGKHGVDVEVQG 130

Human   131 PHEARDGQLLIRLDLNRKEVLTLRLRNGGTQSVTLTHLFPLCRTPQFAFYNEDQELPCPLGPGEC 195
            ||||||||||||||||||||||||||||||:.||||||||||.||||.||:.:|:|||||||||.
  Rat   131 PHEARDGQLLIRLDLNRKEVLTLRLRNGGTKPVTLTHLFPLCWTPQFVFYHGEQDLPCPLGPGES 195

Human   196 YELHVHCKTSFVGYFPATVLWELLGPGESGSEGAGTFYIARFLAAVAHSPLAAQLKPMTPFKR-T 259
            |||||:||||.|||||||||||||||||||:|||.||||||||||||||||||||||.||||| .
  Rat   196 YELHVYCKTSIVGYFPATVLWELLGPGESGAEGAETFYIARFLAAVAHSPLAAQLKPTTPFKRPP 260

Human   260 RITGNPVVTNRIEEGERPDRAKGYDLELSMALGTYYPPPRLRQLLPMLLQGTSIFTAPKEIAEIK 324
            |:|.|||.||||||||||||||||:||||:||||||||.|||||||.||||.||||:|||:||||
  Rat   261 RLTRNPVSTNRIEEGERPDRAKGYELELSLALGTYYPPIRLRQLLPTLLQGPSIFTSPKEVAEIK 325

Human   325 AQLETALKWRNYEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRP 389
            |||||.||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 AQLETTLKSRNYEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRP 390

Human   390 SVLRGDHLFALLSSETHQEDPITYKGFVHKVELDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPL 454
            |||||||||||||||..||||:|||||||||||||||||||.|||||||||||||||||||||||
  Rat   391 SVLRGDHLFALLSSEIQQEDPVTYKGFVHKVELDRVKLSFSPSLLSRFVDGLTFKVNFTFNRQPL 455

Human   455 RVQHRALELTGRWLLWPMLFPVAPRDVPLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAP 519
            |||||||||||||:|||.|||||.|.|.|||||||.|||||||||||||||||:|||.|||||||
  Rat   456 RVQHRALELTGRWVLWPTLFPVASRGVSLLPSDVKFKLYDRSLESNPEQLQAMKHIVRGTTRPAP 520

Human   520 YIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRD 584
            ||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||
  Rat   521 YIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRLRVHLPSSIYRLLAPSRD 585

Human   585 IRMVPEDIKPCCNWDAKKGEYVFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGH 649
            |||||||||.|||||.||||||:||||.||:|||||||||||.||||||||||||||||||||||
  Rat   586 IRMVPEDIKTCCNWDPKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGH 650

Human   650 CMEPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYK 714
            ||||||||||||||:|||||:||||||||||||||||||||||.|||||||||||||||||||||
  Rat   651 CMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLAQKHGLGYSLLERLLTYNSLYK 715

Human   715 KGPDGYDPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFH 779
            |||:|||||||||||||||||||||||||||||:||||||||||||||||||.|||:||||||||
  Rat   716 KGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERFCRWEGLPQQGFPIIFH 780

Human   780 GVMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCI 844
            ||||||||||||||||||||||||||||:.|||||||||||||||||||||||||||||||||||
  Rat   781 GVMGKDEREGNSPSFFNPEEAATVTSYLRQLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCI 845

Human   845 TKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAV 909
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   846 TKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAV 910

Human   910 TRAKALLIIVGNPLLLGHDPDWKVFLEFCKENGGYTGCPFPAKLDLQQGQNLLQGLSKLSPSTSG 974
            ||||||||:||||||||||||||.||||||||||||||||||||||||||:||||||||||||||
  Rat   911 TRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGYTGCPFPAKLDLQQGQDLLQGLSKLSPSTSG 975

Human   975 PHSHDYLPQEREGEGGLSLQVEPEWRNEL 1003
            |..|..||||||||.||.|||||||||||
  Rat   976 PRRHQRLPQEREGEEGLPLQVEPEWRNEL 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	221/234 (94%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	197/204 (97%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965		41/43 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003		30/36 (83%)
Mov10	NP_001101181.1	DEXXQc_Helz-like	499..734	CDD:350796	221/234 (94%)
		SF1_C_Upf1	735..940	CDD:350195	197/204 (97%)