Protein Alignment MOV10 and upf1

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_593080.1
• Gene: upf1 / 2542327
• PomBaseID: SPAC16C9.06C
• Length: 925
• Species: Schizosaccharomyces pombe
• Alignment Length: 806
• Identity: 218/806 - (27%)
• Similarity: 335/806 - (41%)
• Gaps: 197/806 - (24%)

Human   301 RQLLPMLLQGTSIFTAPKEIAE-----IKAQLETALK--WR-----NYE-------------VKL 340
            ||.||.|:      |.|.|..:     |.:|....|:  ||     |.|             |:|
pombe   157 RQFLPWLI------TPPSEEEQKLAIPITSQQMVRLEELWRKDPNANLEDLDKPIEDDSLPSVEL 215

Human   341 R---------LLLHLEELQMEHDIRHYDLES---VPMTWDPVDQNPRLLTLEVPGVTESRPSVLR 393
            |         :|..|.:.:.::|.|..:.::   |.:.||............:|.:......:..
pombe   216 RYKDAHAYQAVLSPLIQAEADYDKRLKESQTQKDVVVRWDQAINKRYTAWFLLPKLESGEIRLAI 280

Human   394 GDHLFALLSSETHQEDPITYKGFVHKVE---LDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLR 455
            ||.:  .|:.|.....|.:..|:|.|:.   .|.|.|....|..........|.|::.:......
pombe   281 GDEM--KLTYEGELRAPWSSTGYVIKIPNNVSDEVGLELKRSDKVPIECTHNFSVDYVWKSTSFD 343

Human   456 VQHRALEL---TGRWLLWPMLFPVAPRDVPLLPSDVKLKL-YDRSLES----NPEQLQAMRHIVT 512
            ....||.|   .|..|...:...:...|:|  ||.:|.|| .|.|:.:    |..|.:|:|.::
pombe   344 RMQTALRLFATDGSRLSSFLYHKLLGHDIP--PSFLKPKLPSDLSVPNLPKLNASQSEAVRAVL- 405

Human   513 GTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLP-------KAH--ILACAPSNSGADLLCQRL- 567
              ::|.. :|.||||||||||..    .||.||.       |:|  :|.|||||...|.|.:::
pombe   406 --SKPLS-LIQGPPGTGKTVTSA----SVVYHLATMQSRKRKSHSPVLVCAPSNVAVDQLAEKIH 463

Human   568 RVHLPSSIYRLLAPSRDIRMVPEDIKPCCNW--------------------------------DA 600
            |..|  .:.|:.|.||      |||:...::                                |.
pombe   464 RTGL--RVVRVAAKSR------EDIESSVSFLSLHEQIKNYKFNPELQRLLKLRSENNELSIQDE 520

Human   601 KKGEYVFPAKKK--LQEYRVLITTLITAG-RLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGL 662
            ||...:..|.:|  |:...|:..|.:.|| |.:|..    .|..:.||||....|||.::.:  :
pombe   521 KKLRILVAAAEKELLRAAHVICCTCVGAGDRRISKY----KFRSVLIDEATQASEPECMIPL--V 579

Human   663 MEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITK 727
            :..|       |:||.||.:|||||:.:.......|..||.|||:..         |..|   .:
pombe   580 LGAK-------QVVLVGDHQQLGPVVMNKKVALASLSQSLFERLIIL---------GNSP---FR 625

Human   728 LLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLP--RQGFPIIFHGVMGKDEREGN 790
            |:..||.||.:.:.|:..:|||.||  ..|...||..|....|  :...|::|:...|::|...:
pombe   626 LVVQYRMHPCLSEFPSNTFYEGTLQ--NGVTTSERIARHVDFPWIQPDSPLMFYANFGQEELSAS 688

Human   791 SPSFFNPEEAAT----VTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDREL 851
            ..||.|..||:|    ||::|           ::.:.|..:|:::||..|..   |.:..:....
pombe   689 GTSFLNRTEASTCEKIVTTFL-----------RSNVLPEQIGIVTPYDGQRS---YIVQYMQNNG 739

Human   852 RGLDDI-KDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKAL 915
            ....|: |.::|.||:.|||:|:..|::|.||||:       ...:||:.:|:|.|||:||||..
pombe   740 SMQKDLYKAVEVASVDAFQGREKDFIILSCVRSSE-------HQGIGFVNDPRRLNVALTRAKYG 797

Human   916 LIIVGNPLLLGHDPDWKVFLEFCKENG-------------GYTGCP------FPAKLDLQQGQNL 961
            :|::|||.:|.....|..|:..|||.|             ..|..|      |...|::|:..:.
pombe   798 VIVLGNPKVLAKHALWYHFVLHCKEKGYLVEGTLNSLQKFSLTLTPPQKPQKFKRDLNVQRSLSP 862

Human   962 LQGL-SKLSPSTSG-P--HSHDYLPQ 983
            :|.. |.:.||.|. |  :|..||.:
pombe   863 IQNAGSAMLPSFSNLPNLYSSSYLEE 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	79/283 (28%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	65/211 (31%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965		15/62 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003		8/21 (38%)
upf1	NP_593080.1	UPF1_Zn_bind	44..193	CDD:401391	13/41 (32%)
		TIGR00376	278..828	CDD:273041	178/617 (29%)
		DEXXQc_UPF1	392..631	CDD:350797	79/279 (28%)