Protein Alignment MOV10 and rdp1

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_001342838.1
• Gene: rdp1 / 2542198
• PomBaseID: SPAC6F12.09
• Length: 1215
• Species: Schizosaccharomyces pombe
• Alignment Length: 842
• Identity: 158/842 - (18%)
• Similarity: 264/842 - (31%)
• Gaps: 279/842 - (33%)

Human    23 VRGLDMETDRERLRTIYNR----------DFKISFGTPAPGFSSMLYGMKIANLAYVTKTRVRFF 77
            ::.|..|..::.||.|...          ||..||.......:|.::..|:    |||.|.:|..
pombe   407 LKKLSKERAKKFLRLILTSKTALINPSELDFTKSFVFYDLSSASSIHIKKL----YVTPTTLRIV 467

Human    78 R----------------LDRWADVRFPE---KRRMKLGSDISKHHKSLLAKIFYDRAEYLHGKHG 123
            .                .:|:..|:..:   |::::.|||..::.|      .|.|.:.|. .:|
pombe   468 EDSLEAGNRVIRNFKDFANRFMRVQITDEYYKQKIRGGSDGFRNEK------LYSRIQQLL-TYG 525

Human   124 VDVEVQ-------GPHEARD-GQLLIR--LDLNRKEVLTLRLRNGGTQSVTLTHLFPLCRTPQFA 178
            :.|..|       |..:.|: |.....  .|||.|::   |...|....:.....:.......|:
pombe   526 IKVGNQIYEFLAFGNSQLREHGAYFFASGSDLNAKQI---REWMGDFSEINSVSKYAARMGQCFS 587

Human   179 FYNEDQELPCPLGPGECYELHV--------HCKTSFVGYFPATVLWELLGPGESGSEGAGTFYIA 235
            ...|....        |.::.:        ||.|..||....:|:..|
pombe   588 TTKEINRF--------CVDISLQDDIVRNNHCFTDGVGMASLSVIRRL----------------- 627

Human   236 RFLAAVAHS--PLAAQLKPMTPFKRTRITGNPVVTNRIEEGERPDRAKGYDLELSMALGTYYPPP 298
             .|....|.  |.|.|.                            |..||...||:|     ||.
pombe   628 -SLEVKNHDMFPSAFQF----------------------------RMGGYKGVLSLA-----PPT 658

Human   299 RLRQLLPMLLQGTSIFTAPKEIAEIKAQLETAL------KWRNYEVKLRLLLHLEELQMEH---- 353
            :|.     ..||..:|  |:...:......:.|      ::.|..:.::|:..||.|.:|.
pombe   659 KLE-----YHQGNLVF--PRRSQDKFKSFHSTLEVIKISRFSNAHLNMQLITLLEGLGVEKTVFL 716

Human   354 DIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFVH 418
            ::....|..:.   :.::...:.:.:....|.|...:::..|.:.|               ||:.
pombe   717 ELTRSQLSKMN---ESINSKQKSILMLRDNVDEYHSTLIIADFIQA---------------GFLE 763

Human   419 KVELDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWPMLFPVAPRDVPL 483
            :.:      :|:.:||:.:.:   :.:.....:|.:.|.      .|.:||     .||.....|
pombe   764 RDD------AFTENLLNLYYE---WVLRLIKEKQKVSVP------KGAYLL-----GVADETGTL 808

Human   484 LPSDVKLKLYDRSLESNPE-QLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPK 547
            ...      ||.::.|.|| .:|     :|.|:..     ||...|||..|.|.....:|...|.
pombe   809 KGH------YDDAVLSVPEIFIQ-----ITDTSTS-----FGSYSTGKLKTRVIVGLCIVARNPS 857

Human   548 AHILACAPSNSGADLLCQRLR----VHLPSSIYRLLAPSRDIRMVPEDIKPCCNWDAKKGEYVFP 608
            .|        .|...:|:.:|    :||.:.|   :.|:...|.:|   ..|...|....||...
pombe   858 LH--------PGDVRVCKAVRCDELMHLKNVI---VFPTTGDRSIP---AMCSGGDLDGDEYTVI 908

Human   609 AKKKLQEYRVLITTLITAGRLVSAQF----P-IDHFTHIFI-----DEAG------------HCM 651
            ..::|....|....|:.:....|..|    | ||.....|:     |..|            |..
pombe   909 WDQRLLPKIVNYPPLLESSPKKSIDFLEGKPLIDSVKEFFVNYIKYDSLGLISNAWKAWAHDHDN 973

Human   652 EPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKG 716
            .||.:.               |.:.|             .|.:.|.......:..:......|..
pombe   974 NPEGIF---------------GNVCL-------------ELAEMHSKAVDFAKSGVACKMQAKYH 1010

Human   717 PDGYDPQFITKL-LRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPII 777
            |..| |.|:.|. .|::||...:          |::...|     .||.|.:|.|....||:
pombe  1011 PKRY-PDFMQKTKTRSFRSETAV----------GKIFRYA-----ARFQRESGRPATYNPIM 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	54/262 (21%)
		DEAG box	645..648		1/2 (50%)
		SF1_C_Upf1	734..939	CDD:350195	10/44 (23%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003
rdp1	NP_001342838.1	RdRP	471..1037	CDD:461574	134/748 (18%)