DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MOV10 and sen1

DIOPT Version :9

Sequence 1:	NP_001123551.1	Gene:	MOV10 / 4343	HGNCID:	7200	Length:	1003	Species:	Homo sapiens
Sequence 2:	NP_594119.1	Gene:	sen1 / 2541556	PomBaseID:	SPAC6G9.10c	Length:	1687	Species:	Schizosaccharomyces pombe

Alignment Length:	1067	Identity:	227/1067 - (21%)
Similarity:	379/1067 - (35%)	Gaps:	302/1067 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    62 KIANLAYVTKTRVRFFRLDRWADVRFPEKRRMKLGSDISKHHKSLLAKIF--YDRAEYLHGKHGV 124
            |..:|..:.:|....|....|..:...|.|.:.:.|         |.|:|  :...:||.....|
pombe   665 KFDSLILLGETSESLFSFIMWLKINDLELRGIVINS---------LCKLFTKFSNFDYLFEDRTV 720

Human   125 D------VEVQGPHEARD-----GQLLIRLDLNRKEVL------TLRLRNGGTQSVTLTHLFPLC 172
            .      :..|..|.:.|     ..:|.:.....|.||      .:|.....|:.....|:....
pombe   721 TFLTDFIIRKQKAHLSADQCKQLANVLTQASPEAKTVLEQHRLSEMRKTKKQTELTNSAHVIKPS 785

Human   173 RTPQFAF-YNEDQELPCP-LGPGECYELHVHCKTSFVGYFPATVLWELLGPGESGSEGAGTFYIA 235
            .|||... .|..:....| :|..|..:.....|.:|                ||..:.:
pombe   786 PTPQITVKQNTTKSSSAPRMGMLEQLKQEYLTKRNF----------------ESKLKSS------ 828

Human   236 RFLAAVAHSPLAAQLKPMTPFKRTRITGNPVVTNRIEEGERPDRAKGYDLELSMALGTYYPPPR- 299
               |..:..|...::||          .|.:..:..:..:..||.:|.   .|:|.....|..|
pombe   829 ---AVSSRKPTFNEVKP----------ANLLAEDLSDNEDDIDRKQGL---FSLAKANKIPEIRQ 877

Human   300 --LRQLLPMLLQGTSIFTAPKEI--------AEIKAQL--------ETALKWRNYEVKLRLLLHL 346
              .||:  .||..::|...|.:|        |.:||:|        :..|.|.........:|..
pombe   878 QERRQV--QLLSNSTIKMHPSQIRMMTNRNVANVKARLFPSMTDFYKEILSWEPANQSPNPVLKF 940

Human   347 EELQME-----HDIRHYDLESVPM----TWDPVDQNPRLLTLE-VPGVTESR------------- 388
            .:|..:     ..:.||.....||    .|..:......|... |.|:...|
pombe   941 HKLDGKIIDSFKTVEHYMEVLQPMIFMECWSQIQSTKLDLKFSPVEGIMVERTAVNNFVDIGVSV 1005

Human   389 -PSVLRGDHLF--ALLSSETHQEDPITYKGFVHKVELDRV-----------KLSFSMSLLSRFVD 439
             |..|.|..|:  .::|...::||..:.||.....:::|:           :...||.:|::...
pombe  1006 APKDLYGYPLYDTEVVSLAFNKEDASSMKGLCCFAKVERIVRQTNGVLVVLRTLPSMEILNKLQG 1070

Human   440 G-----LTFKVNFTFNRQPLRVQ-----HRALELTGRWLLWPMLFPVAPRDVPLLPSDVKLKLYD 494
            .     |......||.||...::     |.|.:          :....|...|:..|..::|...
pombe  1071 NCALWFLKLTNLATFTRQYAGIRGLPYFHLADD----------IIRARPCSQPVKHSSSEIKAAM 1125

Human   495 RSLESNPEQLQAMRHIV--TGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAH-------- 549
            :..:.|..|.:|:...:  .|.|     :|.||||||||.|::..|..::..|.:.|
pombe  1126 KRYQVNEPQAKAIMCALDNNGFT-----LIQGPPGTGKTKTIIGIISALLVDLSRYHITRPNQQS 1185

Human   550 --------ILACAPSNSGADLLCQRLR---------VHLPSSIYRLLAPS------RDI------ 585
                    ||.|||||:..|.:..||:         .::| .:.|:..|.      ||:
pombe  1186 KSTESKQQILLCAPSNAAVDEVLLRLKRGFLLENGEKYIP-RVVRIGNPETINVSVRDLSLEYQT 1249

Human   586 --------------------------------------------RMVPED--------------- 591
                                                        |.|.||
pombe  1250 EKQLLEVNQGAIDLGSLQELTRWRDTFYDCIQKIEELEKQIDVARDVAEDTKSLGKELQNKINEK 1314

Human   592 ------IKPCCNWDAKKGEYVFPAKKK-----LQEYRVLITTLITAGRLVSAQFPIDHFTHIFID 645
                  ::...:....|.:.|...:||     |::..|:..||..:|..:.|...: :|:.:.||
pombe  1315 NLAEQKVEELQSQSFTKNKEVDLLRKKAQKAILKQADVVCATLSGSGHDLVAHSSL-NFSTVIID 1378

Human   646 EAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYN 710
            ||...:|.::::.:       ..|  ..:.:|.|||.||.|.:.|  .:...|.||        .
pombe  1379 EAAQAVELDTIIPL-------RYG--AKKCILVGDPNQLPPTVLS--KKAASLNYS--------Q 1424

Human   711 SLYKKGPDGYDPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFP 775
            ||:.:....:..| :..|...||.||.|...|::.:|:..|:...::.::.:.. |...|:....
pombe  1425 SLFVRIQKNFSNQ-MCLLSIQYRMHPDISHFPSKKFYDSRLEDGDNMAEKTQQV-WHVNPKFTQY 1487

Human   776 IIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKI 840
            .:| .|.|| ||..|:.|.:|.||...:.:.:..||   :|......:.| :|||:|||.|:.::
pombe  1488 RLF-DVRGK-ERTSNTMSTYNLEEVEYLVNMVDELL---NKFPDVNFTGR-IGVITPYRSQLHEL 1546

Human   841 RYCI-TKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKR 904
            |... .|..:......||:     :|:.|||||:.:|..|.|:|...       ..:|||::.:|
pombe  1547 RRAFKVKYGKSFMSTIDIQ-----TVDGFQGQEKDIIFFSCVKSYSK-------HGIGFLRDFRR 1599

Human   905 FNVAVTRAKALLIIVGNPLLLGHDPDW 931
            .|||:|||::.|:|:||...|..|..|
pombe  1600 LNVALTRARSSLLIIGNMETLKTDDLW 1626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_001123551.1	DEXXQc_Helz-like	498..733	CDD:350796	69/343 (20%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	61/199 (31%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269\|PubMed:22791714	921..965		4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	966..1003
sen1	NP_594119.1	SEN1_N	53..693	CDD:289496	5/27 (19%)
		DNA2	765..1641	CDD:224037	206/958 (22%)
		AAA_19	1137..1212	CDD:289986	25/79 (32%)
		P-loop_NTPase	<1350..>1410	CDD:304359	18/69 (26%)
		AAA_12	1422..1618	CDD:289832	66/223 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810