Protein Alignment MOV10 and dbl8

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_596055.1
• Gene: dbl8 / 2540523
• PomBaseID: SPBC29A10.10C
• Length: 1944
• Species: Schizosaccharomyces pombe
• Alignment Length: 712
• Identity: 172/712 - (24%)
• Similarity: 264/712 - (37%)
• Gaps: 209/712 - (29%)

Human   400 LLSSETHQEDPITYKGF-VHKVE-LDRVKLSFSMSL--------LSRFVDGLTFKVNFTFNRQPL 454
            |||......|....|.| :.|:: :.|.|.|..:.|        |..:...:.|.....||....
pombe  1162 LLSKSQSSGDTNNPKSFQLCKIQSISRKKESLELCLRMNIESIDLQEYAPNIRFTAQKLFNATTS 1226

Human   455 RVQHRALELTGRWLLWPMLFPVAPRDVPLLPS----DVKLKLYDRSLESNPEQLQAMRHIVTGTT 515
            ..:..||: :.|.|  |:...:...:|..|||    |.|.|:. :|...|..|..|   |...:.
pombe  1227 LREFAALK-SLRHL--PLSQRILDANVTRLPSNFTDDKKQKIM-KSYGVNEPQAYA---IYASSV 1284

Human   516 RPAPYIIFGPPGTGKTVTLVEAIKQVV---------------KHLPKAHILACAPSNSGADLLCQ 565
            .....:|.||||||||.|::..|..|:               :...|..||.|||||:..|.:..
pombe  1285 NDGFTLIQGPPGTGKTKTILGMIGAVLTSSSQGLQFNVPGQTRKTSKNKILICAPSNAAIDEILL 1349

Human   566 RLR-------------------------VHLPS-SIYRLLAPSRDIRMVPEDIKPCCNWDAKKGE 604
            |::                         ||... ::...:....::..:.:|.:...:.|.:| :
pombe  1350 RIKAGVYDHEGIKFFPKVIRVGFGDSISVHAKEFTLEEQMIKQMELTNLKKDQEANNSSDTRK-K 1413

Human   605 YVFPAKKK--------------------------------------------------------- 612
            |....||:
pombe  1414 YDSIIKKRDSLREDLEKFRSTGKNSSILEAQLREITKQKNMLEQSLDDMRERQRSTNRNLDVLKK 1478

Human   613 ------LQEYRVLITTLITAGR--LVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETG 669
                  |||..::..||..:|.  |::|...   |..:.||||...:|..|::.:....|
pombe  1479 QIQNQLLQEADIVCATLSASGHELLLNAGLT---FRTVIIDEAAQAVELSSIIPLKYGCE----- 1535

Human   670 DPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRS 734
                ..|:.|||.||.|.:.|..:.|.|...||..|:...::           :....|...||.
pombe  1536 ----SCVMVGDPNQLPPTVLSKTSAKFGYSQSLYVRMFKQHN-----------ESACLLSIQYRM 1585

Human   735 HPTILDIPNQLYYEGEL---QACADVVDRERFCRWAGLPRQGFPIIF--HGVMGKDEREGNSPSF 794
            :|.|...|::.:|..:|   ...:.|..|.    |...|:.|....|  ||.    |...||.|.
pombe  1586 NPEISRFPSKFFYNSKLLDGPNMSAVTSRP----WHEDPQLGIYRFFNVHGT----EAFSNSKSL 1642

Human   795 FNPEEAA--------TVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDREL 851
            :|.|||:        .:..||.:     ..:||       :||::|||.||:::|   ::..|:.
pombe  1643 YNVEEASFILLLYERLIQCYLNI-----DFEGK-------IGVVTPYRSQVQQLR---SQFQRKY 1692

Human   852 RGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALL 916
             |....|.|.:.:|:.|||||:.:|:.|.||||.|       ..:|||::.:|.|||:||||:.|
pombe  1693 -GSIIFKHLDIHTVDGFQGQEKDIIIFSCVRSSMS-------GGIGFLQDLRRLNVALTRAKSSL 1749

Human   917 IIVGNPLLLGHDPDWKVFLEFCKENGGYTGCPFPAKLDLQQGQNLLQGLSKLSPSTSGPHSH 978
            .||||...|..:..:...:|..|..|.:.        ||...|      .|.|.|.|...:|
pombe  1750 YIVGNSKPLMQEDIFYSLIEDAKTRGVWR--------DLSANQ------FKNSKSISNVSTH 1797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	64/340 (19%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	68/217 (31%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965		8/43 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003		5/13 (38%)
dbl8	NP_596055.1	SEN1_N	75..784	CDD:432746
		TIGR00376	1219..1780	CDD:273041	151/630 (24%)
		AAA_12	1560..1756	CDD:463780	72/237 (30%)