Protein Alignment MOV10 and dna2

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_596499.2
• Gene: dna2 / 2540148
• PomBaseID: SPBC16D10.04C
• Length: 1397
• Species: Schizosaccharomyces pombe
• Alignment Length: 609
• Identity: 133/609 - (21%)
• Similarity: 252/609 - (41%)
• Gaps: 145/609 - (23%)

Human   343 LLHLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQ 407
            ::|:::..:|...||    .:.:.|           |::|.....:..|..|:          ::
pombe   823 IVHIQDSCIEVRTRH----RLHIPW-----------LKMPNFDFKKNQVFFGN----------YE 862

Human   408 EDPITYKGFVH-KVELDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWP 471
            :..:::.|..| :..:|:.:.|..::.:                               |..|..
pombe   863 DSKLSFIGSNHTRYRIDKDEFSSGIASI-------------------------------RGTLMS 896

Human   472 MLFPVAPRDVPLLPSDVKLKL----YDRSLESNPEQLQAMRH-IVTGTTR--PAPY--IIFGPPG 527
            .:.|    |.||:..|:.::|    :..|...:||.|:.:.. .:|...:  .|.:  :|.|.||
pombe   897 SVLP----DAPLIIRDMIIRLKPPKFCNSALIDPEFLKCLNEDQITALKKCHAAEHYSLILGMPG 957

Human   528 TGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDI 592
            ||||.|:...|:.::  ..|..||..:.::...|.:..:|: ...|:|.||.:|.:    :...:
pombe   958 TGKTTTISSLIRSLL--AKKKKILLTSFTHLAVDNILIKLK-GCDSTIVRLGSPHK----IHPLV 1015

Human   593 KPCCNWDAKKGEYVFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLV 657
            |..|..:....:.:...|...::.:::..:.:.....:   |....|.:..||||.....|..|
pombe  1016 KEFCLTEGTTFDDLASLKHFYEDPQIVACSSLGVYHSI---FNKRKFDYCIIDEASQIPLPICL- 1076

Human   658 AIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDP 722
               |.:::.|      :.||.||..||.|::::..|.|.||..||      :..|.:|.|:.
pombe  1077 ---GPLQLAE------KFVLVGDHYQLPPLVKNSRTSKDGLSLSL------FKLLSEKHPEA--- 1123

Human   723 QFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPR----QGFP---IIFHG 780
              :|.|...||.:..|..:.::|.|.|.|...:..:.:::..    ||:    .|.|   ...|.
pombe  1124 --VTTLRLQYRMNEDINSLSSELIYGGNLVCGSKTISQKKLI----LPKAHLSDGLPDSSSSLHW 1182

Human   781 VMGKDEREGNSPSFFNPEEAATVTSYLKLLL-----------APSS--KKGKARLSPRSVGVISP 832
            | .|.....:|..|||.::...|.|....:|           |.||  ::|   :...|:|:||.
pombe  1183 V-NKLINPSHSVIFFNTDDILGVESKTNNILENHTEAFLIEQAVSSFLERG---VKQSSIGIISI 1243

Human   833 YRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLG 897
            |:.|||.:.          :.|....::::.:|:.:||:::.:||||.|||:...:..:|
pombe  1244 YKSQVELLS----------KNLKSFTEIEINTVDRYQGRDKDIILISFVRSNSKNLVGEL----- 1293

Human   898 FLKNPKRFNVAVTRAKALLIIVGN 921
             |::..|.|||::|||...|:.|:
pombe  1294 -LRDWHRLNVALSRAKVKCIMFGS 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	56/239 (23%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	53/208 (25%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003
dna2	NP_596499.2	DNA2_N-like	440..663	CDD:411722
		DEXXQc_DNA2	931..1132	CDD:350799	53/231 (23%)
		DNA2	<1040..1334	CDD:440729	83/325 (26%)