Protein Alignment MOV10 and SPOM_SPCC737.07C

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_588369.1
• Gene: SPOM_SPCC737.07C / 2539412
• PomBaseID: SPCC737.07C
• Length: 660
• Species: Schizosaccharomyces pombe
• Alignment Length: 654
• Identity: 167/654 - (25%)
• Similarity: 271/654 - (41%)
• Gaps: 164/654 - (25%)

Human   368 DPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFVHKVELDRVKLSF--- 429
            ||...|..    |:|..:.|...|:.....|.....:...|..|:.:|.|.:|....:.::.
pombe    79 DPAFSNGE----ELPANSFSPGDVVSIRQDFQSSKKKRPNETDISVEGVVTRVHERHISVALKSE 139

Human   430 -----SMSLLS--RFVDGLTFKVNFTFNRQPLRVQHRALELTG-----RWLLWPMLFPVAPRDVP 482
                 |::.||  :.|:.:|::          |::|..||...     |..|:..|......||.
pombe   140 EDIPSSVTRLSVVKLVNRVTYE----------RMRHTMLEFKRSIPEYRNSLFYTLIGRKKADVS 194

Human   483 LLPSDVKL----KLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVK 543
            :   |.||    |.:::.|  |..|.:|::..:......   :|.||||||||.||||.|:|:|
pombe   195 I---DQKLIGDIKYFNKEL--NASQKKAVKFSIAVKELS---LIHGPPGTGKTHTLVEIIQQLV- 250

Human   544 HLPKAHILACAPSNSGADLLCQRL--------RVHLPSSIYRLLAPSRD---------------I 585
             |....||.|..||...|.:..||        |:..|:   |||....|               |
pombe   251 -LRNKRILVCGASNLAVDNIVDRLSSSGIPMVRLGHPA---RLLPSILDHSLDVLSRTGDNGDVI 311

Human   586 RMVPEDIKPCCN--WDAKKGEYVFPAKKKLQEYR--------VLITTLITAGRLV--------SA 632
            |.:.|||..|.:  ...|.|.......|.::|.|        ..:..:::|.::|        |.
pombe   312 RGISEDIDVCLSKITKTKNGRERREIYKNIRELRKDYRKYEAKTVANIVSASKVVFCTLHGAGSR 376

Human   633 QFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHG 697
            |.....|..:.||||...:||:..:.:.|:.:|          :||||..||.|.::|....
pombe   377 QLKGQRFDAVIIDEASQALEPQCWIPLLGMNKV----------ILAGDHMQLSPNVQSKRPY--- 428

Human   698 LGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRN--YRSHPTILDIPNQLYYEGELQACADV--- 757
              .|:.|||:      |...|      :.|...|  ||.|..|...|:..:|:.:|....:|
pombe   429 --ISMFERLV------KSQGD------LVKCFLNIQYRMHELISKFPSDTFYDSKLVPAEEVKKR 479

Human   758 --VDRERFCRWAGLPRQGFPIIFHGVMG---KDEREGNSPSFF-----NPEEAATVTSYLKLLLA 812
              :|.|..   ........||.|:..:|   :|:|..:..:|:     |..||..|:.::..||
pombe   480 LLMDLENV---EETELTDSPIYFYDTLGNYQEDDRSEDMQNFYQDSKSNHWEAQIVSYHISGLL- 540

Human   813 PSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVIL 877
                  :|.|..:.:.|::||..||..||..:.:     :|:    ::::|||::.||:|:..|:
pombe   541 ------EAGLEAKDIAVVTPYNAQVALIRQLLKE-----KGI----EVEMGSVDKVQGREKEAII 590

Human   878 ISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDW-----KVFLEF 937
            .|.|||:      |:. .:|||...:|.|||:||.|..|.::|:    .:...|     ..:::|
pombe   591 FSLVRSN------DVR-EVGFLAEKRRLNVAITRPKRHLCVIGD----SNTVKWASEFFHQWVDF 644

Human   938 CKEN 941
            .:||
pombe   645 LEEN 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	74/277 (27%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	57/222 (26%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965		4/26 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003
SPOM_SPCC737.07C	NP_588369.1	TIGR00376	33..651	CDD:273041	167/654 (26%)