DRSC/TRiP Functional Genomics Resources

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Protein Alignment MOV10 and dbl2

DIOPT Version :10

Sequence 1:NP_066014.1 Gene:MOV10 / 4343 HGNCID:7200 Length:1003 Species:Homo sapiens
Sequence 2:NP_587772.3 Gene:dbl2 / 2538994 PomBaseID:SPCC553.01C Length:715 Species:Schizosaccharomyces pombe


Alignment Length:367 Identity:65/367 - (17%)
Similarity:120/367 - (32%) Gaps:116/367 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   249 QLKPMTPFKRTRITGNPVVTNRIEEGERPDRAKGYDLELSMALGTYYPPPRLRQLLPML-----L 308
            :::|...|:     .|..:.:.:||..|.:....|....|..  |..|.|.....:|:|     .
pombe   178 EIQPKAKFR-----PNSYLASSVEESNRANNTSPYPPSNSSV--TALPKPSKIAYIPVLSKPKSF 235

Human   309 QGTSI----------------FTAPKEIAEIKAQLETALKWRNYEVKLRLLLHLEELQMEHDIRH 357
            .||.:                |::|.  |:::|...|.|...|               ..|.:::
pombe   236 NGTLVEDPVEEFGEDDIASDFFSSPS--ADLEADDFTTLNNSN---------------AGHLLQN 283

Human   358 YDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFVHKVEL 422
            ...::|              ::.|..:......|           |..|...|.:.:.       
pombe   284 LSNDNV--------------SVSVKALENGNEEV-----------SNNHARSPHSSRA------- 316

Human   423 DRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQH-----RALELTGRWLLWPML-FPVAPRD- 480
                   ..::.|...|||    |....||...|..     :.|.||.  |..|:| .|...|. 
pombe   317 -------CNTIPSNKNDGL----NDDHQRQDSSVAEPSPTSKRLRLTR--LPLPLLRKPTGKRQN 368

Human   481 -VPLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKH 544
             :.:..:|....||:||:::..| |.:::::...|....|          .:...::|..:..:|
pombe   369 FINITVTDPSKNLYERSVKTAAE-LASLQNVTETTDNEIP----------NSPDFLDAASEEDEH 422

Human   545 LP----KAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPS 582
            :|    .:.:...|..|..|   .|.::..:||....|:.|:
pombe   423 IPSLDSSSLLTPLALPNKKA---FQPVKFRVPSFSSPLVKPA 461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MOV10NP_066014.1 DEXXQc_Helz-like 498..733 CDD:350796 15/89 (17%)
DEAG box 645..648
SF1_C_Upf1 734..939 CDD:350195
Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714 921..965
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 966..1003
dbl2NP_587772.3 DUF2439 7..78 CDD:463065
Blue background indicates that the domain is not in the aligned region.

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