Protein Alignment MOV10 and sosi-1

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_491376.1
• Gene: sosi-1 / 183377
• WormBaseID: WBGene00016565
• Length: 852
• Species: Caenorhabditis elegans
• Alignment Length: 596
• Identity: 103/596 - (17%)
• Similarity: 174/596 - (29%)
• Gaps: 253/596 - (42%)

Human   257 KRTRITG-NPVVT--------NRIEEGERPDRAKGYDLELSMALGTYYPPPRLRQLLPMLLQGTS 312
            |:..:.| ..:||        ||..:|.|.|..            .:.|.....|||..||.||
 Worm   338 KKLAVCGVTEIVTVSEDTFNDNRAPQGYRADAV------------AFTPVLIPGQLLKSLLPGT- 389

Human   313 IFTAPKEIAEIKAQLETALKWRNYEVKLRLL-------------LHLEELQMEHDIRHYDLESVP 364
                    ..|..:.|||.:.::::::.:::             |||
 Worm   390 --------PHIVVRRETAAQSKSWDLRPQVINFGIMGARKAYPFLHL------------------ 428

Human   365 MTWDPVDQNPRLLTLEVPGVTESRPSVLR-GDH-LFALLSSETHQEDPITYKGFV-HKVELD-RV 425
                     |..:....|...::...|.: |.| |.|::|:....:|...|:..: |..||: .:
 Worm   429 ---------PNYMAGRSPNTEDAWRGVRKLGHHGLSAMISTSNMNQDKFHYETTLQHVRELEGSM 484

Human   426 KLSFSMSLLSRFVDGLTFKVNFTFNRQ-------PLRVQH------------------------- 458
            |:||::....|.|....:|....|:.:       |..|.|
 Worm   485 KVSFALQYPGRPVKACNWKNGTKFSIETPAGTFVPAAVDHAVQSTDAITTIECRILRPADNAVHI 549

Human   459 -----------RALELTGRWLLWPMLFPVAPRDV-----------------PLLPS--------- 486
                       :..|..|..|   ...||.|.|.                 |::.|
 Worm   550 LAVGEDAVLIKQTKEADGHLL---AATPVVPVDTVLDRNKGLATFAALNGGPIIASNGLNYPHKE 611

Human   487 --------------------DVKL---------------KLYDRSLESNPEQLQAMRHIVTGTTR 516
                                |:||               .:...::|.:.:.:|  |.|::....
 Worm   612 FRYQNFVCSAQQSTFIQACCDLKLGALSLDGAFGTGKTKAVAATAIEFSNQNIQ--RVIISANNN 674

Human   517 PAPYII------FGPPGTGKTVTLV-----------------------EAIKQVVKHLPKAHILA 552
            .|...|      ..|.|..|.|..:                       |...:||:.:.:.::..
 Worm   675 GAVKAIHDAIRSLAPRGRVKVVRAMSARLRDEAKPEVLTEDDFPILWREVFTEVVQSVNRPNVRG 739

Human   553 CAPSNSGADLLCQRLRVH--LPSSIYRLLAPSRDIRMVPEDIKPCCNWDAKKGEY--------VF 607
            ..|:...|   .:.|..|  |||.            |:..:|:..|     |..|        ::
 Worm   740 THPAIIDA---ARHLNAHGLLPSP------------MLNNEIRVRC-----KAPYKTEPPAHTIW 784

Human   608 PAKKKLQEYRVLITT---LITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETG 669
            .|..|:.|..::|.|   :.||...:......:....:.:|||...    .::.|.||    .|.
 Worm   785 TALMKIHETAIIIGTTASIHTALNDIGFASKANEIGLVMLDEASQI----PMIKIGGL----ATH 841

Human   670 DPGGQLVLAGD 680
            .|..:.||.||
 Worm   842 FPKAKFVLVGD 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	44/225 (20%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003
sosi-1	NP_491376.1	None