Protein Alignment MOV10 and ego-1

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_492132.1
• Gene: ego-1 / 172524
• WormBaseID: WBGene00001214
• Length: 1632
• Species: Caenorhabditis elegans
• Alignment Length: 660
• Identity: 113/660 - (17%)
• Similarity: 207/660 - (31%)
• Gaps: 228/660 - (34%)

Human   219 LGPGESGSEGAGTFYIARFLAAVAHS-PLAAQLKPMTPF------------KRTRITGNPVVTNR 270
            ||...|.....|.:::.::.::.... ....|:||...|            :...|...|.:..|
 Worm   569 LGSSNSQMRDNGAYFMEKYSSSQCREYERIYQIKPPITFNPKIQAARKNLGRFETIDNIPKMMAR 633

Human   271 IEEGERPDRAKGYDLELSMALGTY-----------------------YPPPRLRQLLPMLLQ-GT 311
            :.:.....|..|.:||....:.||                       |   |..|::..::. |.
 Worm   634 LGQCFTQSRLSGVNLERCTYMTTYDLTGGKNLKGDEYTFSDGVGMMSY---RFAQMVSEVMDFGK 695

Human   312 SI-------FTAPKEIAEIKAQLETALKWR-NYEV---------KLRLLLHLEELQMEHDIRHYD 359
            .:       |...|.:..|:..|:...:|. :|.:         .|..:....:::.... ||
 Worm   696 GVPSCFQFRFRGMKGVISIEPLLDNLRQWSISYNISKPSDDSSWSLNCMFRPSQIKFISK-RH-- 757

Human   360 LESVPMTWDPVDQ-------NPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFV 417
                     |.||       :|      || |..::|.:...|.:..:.|.|.|:.       ..
 Worm   758 ---------PRDQVEIVKYSSP------VP-VALNKPFINILDQVSEMQSLECHRR-------VT 799

Human   418 HKVE--LDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWPMLFPVAPRD 480
            :::|  |||..|||:..:           |:.||.|..|:...|.:::......|.......|..
 Worm   800 NRIEELLDRQMLSFAQQM-----------VDETFCRNRLKELPRRVDIDYLRTTWGFTLSSEPFF 853

Human   481 VPLLPSDVKLKL-------------------------------------YDRSLESNPEQLQAMR 508
            ..|:.:.:|..:                                     |.::|........|.|
 Worm   854 RSLIKASIKFSITRQLRKEQIPIPCDLGRSMLGVVDETGRLQYGQIFVQYTKNLALKLPPKNAAR 918

Human   509 HIVTGTT--RPAPYIIFGPPGTGKTVTLVEAIK--------QVV---KHLPKAHILACAPSN-SG 559
            .::|||.  ...|.|:.|      .|.:.||:.        .||   :|.|:.|     |.. :|
 Worm   919 QVLTGTVLLTKNPCIVAG------DVRIFEAVDIPELHHMCDVVVFPQHGPRPH-----PDEMAG 972

Human   560 ADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKPCCNWDAK----KGE--YVFPAKKK------ 612
            :|         |....|.::                  ||.:    |.|  |.|.::|:
 Worm   973 SD---------LDGDEYSII------------------WDQQLLLDKNEDPYDFTSEKQKASFKE 1010

Human   613 ------LQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCME--PESLVAIAGLMEVKETG 669
                  ::|:.|....|.:.|::.::..   |.:..:...|..||:  .::..|:    :..::|
 Worm  1011 DEIDDLMREFYVKYLKLDSVGQISNSHL---HNSDQYGLNARVCMDLAKKNCQAV----DFTKSG 1068

Human   670 DPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRS 734
            .|         |.:|....|........:.....||:..|:......|....|:...||.|.:::
 Worm  1069 QP---------PDELERKWRKDEETGEMIPPERAERVPDYHMGNDHTPMYVSPRLCGKLFREFKA 1124

Human   735 HPTILDIPNQ 744
            ...:|.|..:
 Worm  1125 IDDVLKISEE 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	50/268 (19%)
		DEAG box	645..648		0/2 (0%)
		SF1_C_Upf1	734..939	CDD:350195	2/11 (18%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003
ego-1	NP_492132.1	RdRP	503..1121	CDD:461574	110/645 (17%)