Protein Alignment MOV10 and rrf-1

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_001250555.1
• Gene: rrf-1 / 172523
• WormBaseID: WBGene00004508
• Length: 1601
• Species: Caenorhabditis elegans
• Alignment Length: 788
• Identity: 137/788 - (17%)
• Similarity: 241/788 - (30%)
• Gaps: 303/788 - (38%)

Human   307 LLQGTSIFTAPKEIAEIKAQLETAL----------------------KWRNYEVKL--------- 340
            |::.:..|:..|::.:.:.|:.:.|                      ..:||:.||
 Worm   824 LIKASIKFSITKQLCKEQIQIPSELGRSMLGVVDETGRLQYGQIFVQYTKNYKKKLPPRDSNNKV 888

Human   341 --------RLLLHLEELQMEHDIRHYDLESVPMTWDPVD------QNPRLLTLEVPGVTESRPSV 391
                    .:||......:..|:|.::...:|......|      ..||      |...|...|.
 Worm   889 HGSEIVTGTVLLTKNPCIVPGDVRIFEAVDIPELHHMCDVVVFPQHGPR------PHPDEMAGSD 947

Human   392 LRGDHLFALLSSE---THQEDPITYKGFVHKVELDRVKLSFSM---------------------- 431
            |.||....:...|   ...|:|..:.....||..||.||...|
 Worm   948 LDGDEYSVIWDQELLLERNEEPFDFAVEKIKVPYDREKLDVLMREFYVTYLKLDSVGQISNSHLH 1012

Human   432 -----SLLSRFVDGLTFK----VNFTFNRQPLRVQHRALELTGRWLLWPMLFPVAPRDVPLLPSD 487
                 .|.||....|..|    |:||.:.||      ...|..:|...|:.|.|.|.:
 Worm  1013 NSDQYGLNSRVCMDLAKKNCQAVDFTKSGQP------PDPLETKWRADPVTFEVIPPE------- 1064

Human   488 VKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILA 552
                        |||::... |:  |..|...|:  .|...||.....:||..|:|...:..
 Worm  1065 ------------NPERIPDF-HM--GNERSPMYV--SPRLCGKLFREFQAIDNVIKISEERD--- 1109

Human   553 CAPSNSGADLLCQRLRVHLPSSIY-------------RLLAPSRDIRMVPEDIKPCCNWDAK-KG 603
                        ::..:.|..:|:             :|.:.:..:|.:.|      |:..: :|
 Worm  1110 ------------EQYNIELDETIFVTGFERYMESAQKQLSSYNGQLRSIME------NYGIRSEG 1156

Human   604 EY----VFPAKKKLQE--------YRV--LITTLITAGRLVSAQFPIDHFTHIFIDEAG------ 648
            |.    :...:.::.:        |..  :|.|.:|:  ||.      .|...|.:|.|
 Worm  1157 EIMSGCIVEMRNRISDKDQDDMSFYNTNQMIETKMTS--LVC------KFRETFFEEFGGFTVKC 1213

Human   649 ---------------HCMEPESLV---AIAG--------------------------LMEVKETG 669
                           .|.:|:..|   |:|.                          :.:||||.
 Worm  1214 TLLPNAYDNGNCLNYRCEDPDQEVRKKAVAWYRACYECAQSTREVRKLSFAWIAYDVIAKVKETN 1278

Human   670 DPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLER-----LLTYNSLYKKGPDGYDPQFITKLL 729
                  ||..:..|:|..  :|:       |:.||.     |:.:::.:|...:      :..|:
 Worm  1279 ------VLNNERMQIGGA--NPM-------YTFLEEHRKQYLIDHDADFKNFCE------LDHLI 1322

Human   730 RNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSF 794
            ...:|...|..:  ::|.|                   .:|  |...:|..:|    |.|.|...
 Worm  1323 TGEKSKEAISIL--KIYLE-------------------MIP--GLDSVFFMLM----RWGESLRL 1360

Human   795 FNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKD 859
            |:.:.......:|..:|..:.:...|.      |...|:.|.:||..|...|.|.....:|.:.:
 Worm  1361 FDGKPIKIYHFFLMFILFATRQLASAD------GNAEPFFKIIEKEEYEKQKRDSSRGNIDPLTE 1419

Human   860 LKVGSVE----EFQG----QERSVILISTVRSSQSFVQ--------------LDLDFNLGFLKNP 902
            .|...:.    :|.|    ::.|.:....:..|..|::              .::.|||.|.:.|
 Worm  1420 KKRSDMMVKFFQFMGCRKFRKMSTLSFCPLNFSSIFMRGEWRIFHESALKTYYNILFNLRFEELP 1484

Human   903 KRFNVAVT 910
            ...:..:|
 Worm  1485 VSSDPTIT 1492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	52/317 (16%)
		DEAG box	645..648		1/2 (50%)
		SF1_C_Upf1	734..939	CDD:350195	36/199 (18%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003
rrf-1	NP_001250555.1	RdRP	479..1094	CDD:461574	59/305 (19%)