Protein Alignment MOV10 and fncm-1

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_491543.1
• Gene: fncm-1 / 172159
• WormBaseID: WBGene00018908
• Length: 783
• Species: Caenorhabditis elegans
• Alignment Length: 897
• Identity: 158/897 - (17%)
• Similarity: 292/897 - (32%)
• Gaps: 283/897 - (31%)

Human    81 RWADVRFPEKRRMKLGSD---------------ISKHHKS-LLAKIFYDRAEYLHGKHGVDVEVQ 129
            :||:..  :|...|.|.|               |.|:.|: ||||.|.|    :|| :|:...:.
 Worm    68 KWAETL--QKSSEKAGRDWLNPFPIRVSSAKKEIEKNSKTELLAKGFDD----IHG-NGIFYPIN 125

Human   130 GPHEARDGQLLIRLDLNRKEVLTLRLRNGGTQSVTLTHLFPLCRTPQFAFYNEDQELPCPLGPGE 194
            .|             :...|:..|:..:.....|.|         |..:          |..||.
 Worm   126 EP-------------IRNFELNLLKCLSSSNCCVAL---------PSSS----------PSTPGR 158

Human   195 CYELHVHCKTSFVGYFP-ATVLWELLGPGESGSEGAGTFYIARFLAAVAHSPLAAQ---LKPMTP 255
            ...:.|.   :|:.:|| ..||  |:...:|            :::::....|.:|   |..:|.
 Worm   159 ICAMTVF---NFLKWFPRCRVL--LVSSSDS------------WISSLRQLGLESQTTKLTTVTQ 206

Human   256 FKRTR-------ITGNPVVTNRIEEGERPDRAKGYDLELSMALGTYYPPPRLRQLLPML------ 307
            ||..:       :...|....::.|.   ...:.:..|:.:.|....|.....:..|:|
 Worm   207 FKNLKTEAGKILVCTTPQCALKVVES---TGGREFLEEIRLVLMELKPNECCSKYKPILNALTVK 268

Human   308 -------LQGTSIFTAPKEIAEI--KAQLETALKWRNYEVKLRLLLHLEELQMEHDIRHYDLESV 363
                   :..||...|.:..|.|  :.|:.|.|:..::         :|:.:.:...|.   .::
 Worm   269 ETFFRCSVLTTSTSNASRRTASITKRQQMITNLQLSDW---------IEQTEADFAFRS---ANI 321

Human   364 P-----MTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPI-----TYKGFVH 418
            |     .||...|.:.:  ..|:.|..|........|.....:.|....:..|     |.|....
 Worm   322 PAGVEVKTWKSEDNSAK--HAEITGKFEKYCEKTIDDLARQCIVSSKSVKKLIWTCWKTLKQQSK 384

Human   419 KVELDRVKLSFSMSLLSRF----VDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWPMLFPVAPR 479
            ..|:::.||..|..|...:    :||:....||.  ::...:.|  ::.....:|.|.:|
 Worm   385 LPEIEKKKLEISEFLTCTYKLLIIDGVVAARNFV--KKHSEIPH--IKEHAEKILEPTIF----- 440

Human   480 DVPLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKH 544
                           ......|.:.|.:.                        ..:||..::..|
 Worm   441 ---------------GGFSEFPAKFQQLS------------------------DSIEAFLKMDNH 466

Human   545 LPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSR--DIRMVPEDIKPCCN-WDAKKGEYV 606
            :  ..::.|..|:...::          .:...|...:|  .:|::.|...|..| |:.::...|
 Worm   467 V--LGVILCRDSDQAIEI----------QNYLELQLTTRCTCVRIIEEGTHPGRNLWNIQRISTV 519

Human   607 FPAKK--KLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETG 669
            |..:|  |:....|.|...|.    .|...|:...|.|            :.::...|...:..|
 Worm   520 FIDRKSPKIVILPVKIRDFIG----FSDGLPLSELTFI------------ASISRDSLFNFRRFG 568

Human   670 DPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLY-----KKGP-----DGYDPQF 724
              |..|::..||.:       .|..:.|       |||..:..:     |..|     :.||.:|
 Worm   569 --GAHLLIINDPLE-------KLRNEDG-------RLLVDDGKFVQNNSKNAPKMGAVERYDFKF 617

Human   725 ITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHGVMGKDE--- 786
            ....||...:|     :|.|.:|..::....|        ..||:.:.|..   |..|...|
 Worm   618 EPSRLRIDATH-----LPIQFFYPRDVGVTFD--------ETAGISQLGKT---HIEMTSKEHTE 666

Human   787 --REGNSPSFFNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDR 849
              :...:|.|...:....|...|:.|..|:..|        |:.:     :::::.:.|   .::
 Worm   667 LFKRLQNPDFSRFQRRKRVFWVLEDLEHPNENK--------SIPI-----EEMDETQLC---WNQ 715

Human   850 ELRGLDDIKDLKVGS----------VEEFQGQERSVILISTVRSSQSFVQLD 891
            :::.|.:||..|:..          ||....::|....|:.:.|:...|.||
 Worm   716 DIQYLGEIKSSKLSERLTRYMKDEPVEWIINEKRRFEYINEITSTDRLVHLD 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	43/249 (17%)
		DEAG box	645..648		0/2 (0%)
		SF1_C_Upf1	734..939	CDD:350195	32/173 (18%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003
fncm-1	NP_491543.1	None