Protein Alignment MOV10 and eri-7

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_491374.2
• Gene: eri-7 / 172047
• WormBaseID: WBGene00016566
• Length: 625
• Species: Caenorhabditis elegans
• Alignment Length: 535
• Identity: 130/535 - (24%)
• Similarity: 198/535 - (37%)
• Gaps: 152/535 - (28%)

Human   492 LYDRSLESNPEQLQAMRHIVTGTTRP--------------APY--------------------II 522
            :|..:||.|||.|.....:.:..|.|              .|:                    .|
 Worm    23 VYQYTLEDNPESLTLQDVLESHMTDPIELNSFDSMEKEAGIPFSNEKQRTAIKMALNENRKLVCI 87

Human   523 FGPPGTGKTVT-------LVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVH----LPSSIY 576
            .||||||||.|       |::..||||...|....||.....:...|....::||    :.::.|
 Worm    88 QGPPGTGKTFTLTLLLCRLIQQKKQVVVLAPTREALANIRMMTKKTLKRMGIKVHEHALMDTNEY 152

Human   577 R-LLAPSRDIRMVPEDIKPCCNWDAKK----GEYVFPAKKKLQEYRVLITTLI------------ 624
            | ::..|....|..|:::     |.:|    ||.   .:..|.|.|..|...:
 Worm   153 RDVINKSDRALMAAEEVR-----DLRKAFDNGEI---TENVLDEMRQSIINRVRNEVGAEVIGNV 209

Human   625 -TAGRLVSAQFPIDHFTH-------IFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDP 681
             .|...:.|.|......|       ..||||...||.::..|:..:.          ::|:||||
 Worm   210 RVAFATIGASFVDFVMKHKKFDPCLCIIDEAAQVMEAQTWPAVYKMK----------RIVMAGDP 264

Human   682 RQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRN-YRSHPTILDIPNQL 745
            :||..::.:...:..||..|:::|:|.     ||.      .|...:|.| |||:..|....|..
 Worm   265 KQLPALVFTDEAKAFGLQNSVMDRILE-----KKN------NFSWIMLENQYRSNAKIATWSNTC 318

Human   746 YYEGELQACADVVDRERFCRWAGLP-----RQGF-PIIF-----------------HGVMGKDER 787
            :|..:|:  .||...|........|     |..| |::.                 |.|.  |..
 Worm   319 FYHNQLK--TDVKCHEYSLHTILNPQPKKFRNLFDPLVLIDTSLERDVEKRLETYEHAVF--DTN 379

Human   788 EGNSP----SFFNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLD 848
            ..|..    |:.|..||.....:.:.||       |..:.|..:.:|:||:.|..    .:|||.
 Worm   380 SINKTKQGFSYANLAEAKIAIGHYQRLL-------KYGVQPSDIAIITPYKGQTS----LVTKLM 433

Human   849 REL---RGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVT 910
            .|.   .|..|.....:|:|:..||:|..|::.:.|||:..       ..:||:...:|.||.:|
 Worm   434 EEFGAETGYTDFVQTTIGTVDSVQGKEYEVVIFTMVRSNPR-------KTMGFVSELRRLNVVIT 491

Human   911 RAKALLIIVGNPLLL 925
            |||...:.:||..||
 Worm   492 RAKRHFMFIGNGYLL 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	70/305 (23%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	56/222 (25%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003
eri-7	NP_491374.2	TIGR00376	20..510	CDD:273041	130/535 (24%)