Protein Alignment MOV10 and smg-2

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_490829.1
• Gene: smg-2 / 171696
• WormBaseID: WBGene00004880
• Length: 1069
• Species: Caenorhabditis elegans
• Alignment Length: 755
• Identity: 200/755 - (26%)
• Similarity: 317/755 - (41%)
• Gaps: 153/755 - (20%)

Human   301 RQLLPMLLQGTSIFTAPKEIAEIKAQLETALK-------WRNY------------------EVKL 340
            :|||      :.|...|.|....:|:..||.:       ||::                  .|:|
 Worm   208 KQLL------SWIVNVPSEEQVARARKITATQAVRMEELWRDHPEATVDDLNKPGLDREPDHVQL 266

Human   341 RLL-LH--------LEELQMEHDIRHYDLESV---PMTWDPVDQNPRLLTLEVPGVTESRPSVLR 393
            |.: .|        |..::.|:|.|..:..|.   .:.|:...:...|....:|...:....:.:
 Worm   267 RYVDAHHYSKVFRPLVAIEAEYDRRVKESASQAVGTVRWEQGLRQSVLAFFHLPQFADGVMKLAK 331

Human   394 GDHLFALLSSETHQEDPITYKGFVHKV---ELDRVKLSFSMSLLSRFVDG-LTFKVNFTFNRQPL 454
            ||.| .|..|:|......|..|.|.|:   ..|.|.:....::....::. :.|.|:..:|....
 Worm   332 GDEL-RLKHSQTVDGSEWTKIGSVFKIPDNHGDEVGIEIRGAVDKSVMESRIMFTVDVVWNATTF 395

Human   455 RVQHRALE--LTGRWLLWPMLFPVA---PRDVPLLPSDVKLKLYDRSL-ESNPEQLQAMRHIVTG 513
            ..|::||.  |.....:.|.|:...   |.:..:|..|:..:|....| |.|..|:||::.::
 Worm   396 ERQYKALAALLNDSKAISPYLYQKLLGHPAEEMMLKFDLPRRLSVAGLPELNSSQMQAVKQVL-- 458

Human   514 TTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHL---PKAHILACAPSNSGAD-------------- 561
             |||.. :|.|||||||||  |.|  .:|.||   .:.::|.|:|||...|
 Worm   459 -TRPLS-LIQGPPGTGKTV--VSA--TIVYHLVQKTEGNVLVCSPSNIAVDHLAEKIHKTGLKVV 517

Human   562 LLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKPCCNWDAKKGEYVFP------AKKKLQEYRVLI 620
            .||.|.|.|..:::..|....:...|...:::.......:.||..|.      ..|:::|:.:|.
 Worm   518 RLCARSREHSETTVPYLTLQHQLKVMGGAELQKLIQLKDEAGELEFKDDLRYMQLKRVKEHELLA 582

Human   621 TTLI---TAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPR 682
            ...:   |......|:........:.|||:....|||.||:|  :..|:       ||||.||..
 Worm   583 AADVICCTCSSAADARLSKIRTRTVLIDESTQATEPEILVSI--MRGVR-------QLVLVGDHC 638

Human   683 QLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRSHPTILDIPNQLYY 747
            |||||:........||..||.|||:..         |..|   .:|...||.||.:.:.|:.::|
 Worm   639 QLGPVVICKKAAIAGLSQSLFERLVLL---------GIRP---FRLQVQYRMHPVLSEFPSNVFY 691

Human   748 EGELQACADVVDRERFC-----RWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYL 807
            :|.||  ..|.:.:|..     .|   |:...|..|....|.:|...:..||.|..|||.|...:
 Worm   692 DGSLQ--NGVTENDRHMTGVDWHW---PKPNKPAFFWHCSGSEELSASGTSFLNRTEAANVEKLV 751

Human   808 KLLLAPSSKKGKARLSPRSVGVISPYRKQVEKI-RYCITK--LDRELRGLDDIKDLKVGSVEEFQ 869
            ..|:       ||.:.|..:|||:||..|...| .|..|:  |:.:|     .:::::.||:.||
 Worm   752 SKLI-------KAGVQPHQIGVITPYEGQRSFIVNYMHTQGTLNSKL-----YENVEIASVDAFQ 804

Human   870 GQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVF 934
            |:|:..|:::.|||:      |: ..:|||.:|:|.|||:||||..|::|||..:|.....|...
 Worm   805 GREKDYIIVTCVRSN------DI-LGIGFLSDPRRLNVAITRAKYGLVLVGNAKVLARHDLWHEL 862

Human   935 LEFCKENGGYTGCPFPAKLDLQQGQ-NLLQGLSKLSPSTS 973
            :...|           :|..|.:|. |.|:.|:...|..:
 Worm   863 INHYK-----------SKEMLYEGPINALKPLNLALPKAT 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	75/260 (29%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	66/212 (31%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965		9/44 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003		1/8 (13%)
smg-2	NP_490829.1	UPF1_Zn_bind	93..243	CDD:401391	10/40 (25%)
		1B_UPF1-like	297..387	CDD:394815	17/90 (19%)
		DEXXQc_UPF1	445..677	CDD:350797	75/260 (29%)
		AAA_12	654..851	CDD:463780	75/232 (32%)