Protein Alignment MOV10 and Y106G6D.5

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: NP_001300390.1
• Gene: Y106G6D.5 / 13181740
• WormBaseID: WBGene00014965
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 498
• Identity: 132/498 - (26%)
• Similarity: 213/498 - (42%)
• Gaps: 113/498 - (22%)

Human   473 LFPVAPRDVPLLPSDVKLKLYDRSLES-----NPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTV 532
            |..:|.|.:| :||     ::||.:.:     ||.|:.|:...:  .|:.....|.||||||||.
 Worm   197 LVNLAYRSIP-MPS-----IHDRKIGNLPETLNPSQVAAVSAAM--NTQRNLLCIQGPPGTGKTR 253

Human   533 TLVEAIKQVVKHLPKAHILACAPSN----SGADLLCQRLRVHLPSSIYR----LLAPSRD----- 584
            .:.|.:.|::|  .|..:|.|||::    :..|....|:...:|.....    |||.::|
 Worm   254 VIAEIVHQLMK--KKKKVLVCAPTHVAVRNAMDATTGRMIEEMPEEKAEQQLCLLANTKDEFQNH 316

Human   585 -----IRMVPEDIKPCCNWDAKKGEYVFPAKKKLQ-EYRVL------------ITTLITAGRLVS 631
                 :..:.:.:......|        |..||:. ||.::            :....|.|....
 Worm   317 KSASKLEEIKKQLSTMSTSD--------PLYKKMSYEYYLIRNSIFRSIFYPKLAVFSTLGTSSI 373

Human   632 AQFPIDHFTH--IFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQ 694
            .:.|..|:..  :.:|||..|.||.:.|.:......|       :|:|.||.:||..|:.|....
 Worm   374 QKLPEYHWNADVMIVDEAAQCTEPATWVPVLTTPSCK-------KLILVGDQKQLPAVVLSDKAM 431

Human   695 KHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLL-RNYRSHPTILDIPNQLYYEGELQA---CA 755
            |.....||:|:|          .:.:....|..|| ..||.:..|::..|:::||.:|.|   .:
 Worm   432 KGNFKLSLMEKL----------AEEFSSNNINILLNEQYRMNKKIMNWSNEVFYENQLTAHSTVS 486

Human   756 DVVDRERFCRWAGLPRQ---GFPII---FHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPS 814
            |:..|: .|  ..||..   ..||:   ...|..:...|..|.||.|.:|...||.|:..|:...
 Worm   487 DITLRD-IC--PNLPEDHVLNNPIMMINMENVKDRSHEEFESHSFTNTDELNLVTEYVNRLVVDL 548

Human   815 SKKGKARLSPRSVGVISPYRKQVEKIRYCIT-KLDRELRGLDDIKDLKVGSVEEFQGQERSVILI 878
            .      ::|:::.|||||..|:||:|..|. ::|             |.:|:.|||.||.|::.
 Worm   549 G------INPKAIAVISPYYAQIEKLRRSIPFRVD-------------VNTVDAFQGHERQVVIF 594

Human   879 STVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGN 921
            ..||.:.       :..:|||...:|.|||||||:...:::||
 Worm   595 CLVRDND-------EGQIGFLNETRRLNVAVTRARRQFVLIGN 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	63/273 (23%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	59/198 (30%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003
Y106G6D.5	NP_001300390.1	TIGR00376	55..653	CDD:273041	132/498 (27%)