Protein Alignment MOV10 and mov10

DIOPT Version :10

• Sequence 1: NP_066014.1
• Gene: MOV10 / 4343
• HGNCID: 7200
• Length: 1003
• Species: Homo sapiens
• Sequence 2: XP_002932163.1
• Gene: mov10 / 100491926
• XenbaseID: XB-GENE-483538
• Length: 972
• Species: Xenopus tropicalis
• Alignment Length: 974
• Identity: 475/974 - (48%)
• Similarity: 632/974 - (64%)
• Gaps: 56/974 - (5%)

Human    54 FSSMLYGMKIANLAYVTKTRVRFFRL--------DRWADVRFPEKRRMKLGSDISKHHKSLLAKI 110
            ||.:::|::.|..|.:|:.|::..:.        |::..:|..:.:..|..:|.|.  ....|:.
 Frog    29 FSQVIFGLRAAGKAKMTQDRIQLKKFLSKTVSLPDQYLAIRKDQAQHAKASADGSS--TGTQAQR 91

Human   111 FYD----RAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTQSVTLTHLFPL 171
            |.:    |.|::..|:|:.:..:  ::..||::...|.|..:::..:.::|..::||..|....|
 Frog    92 FTEWMKRRTEFISDKNGISISSE--YDLSDGRIRFHLPLEEEKIFPIIIQNKSSESVIFTQYKVL 154

Human   172 CRTPQFAF---YNEDQELPCPLGPGECYELHVHCKTSFVGYFPATVLWELLGPGESGSEGAGTFY 233
            .:...|:|   |......|..|.||:.||:.|:..|:..||||.|:::|......|.|     |:
 Frog   155 RKMRIFSFEDEYKVSLSKPIKLAPGDEYEIKVYSCTAHYGYFPITLVFEFRRDSNSPS-----FH 214

Human   234 IARFLAAVAHSPLAAQLKPMT---PFKRTRITGNPVVTNRIE-EGERPDRAKGYDLELSMALGTY 294
            |.|||:||::|.||.:|.|.:   ||:|.  ...|:  .||| :|..|:.:..|:||..:.||.:
 Frog   215 IGRFLSAVSNSKLAERLGPTSKYIPFQRN--FRKPI--KRIEDDGFPPESSLNYELEREIPLGDF 275

Human   295 YPPPRLR-QLLPMLLQGTSIFTAPKEIA-EIKAQLETALKWRNYEVKLRLLLHLEELQMEHDIRH 357
            .||..|| .::..|...:...|:...:. :.:..|.::|.:.||..|..||:||||:|||.|||.
 Frog   276 TPPHNLRSDIINGLFANSGSTTSSSSVGNDHRDLLASSLAFSNYSKKFHLLMHLEEIQMELDIRR 340

Human   358 YDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFVHKVEL 422
            ||.....|..||.|:  |||.|.||||.|:|||||||||||..||.|..:...|:|||:||.|||
 Frog   341 YDRTDQLMEHDPRDK--RLLILNVPGVAENRPSVLRGDHLFVTLSDERGKPGIISYKGYVHGVEL 403

Human   423 DRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWPMLFPVAPRDVPLLPSD 487
            :||||.||.:||.||::||.|.|.|||||.||::||||:.:.....|..:|||.|.....:..|.
 Frog   404 ERVKLGFSQNLLRRFLNGLYFDVTFTFNRLPLKIQHRAVNVAKDKNLDQILFPEASHGKCITDSQ 468

Human   488 VKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILA 552
             :|.||||.|||||||..|::.|::|.:|||||:||||||||||||||||||||||.:|..|:||
 Frog   469 -RLILYDRILESNPEQYNAVKQILSGISRPAPYLIFGPPGTGKTVTLVEAIKQVVKCIPNCHVLA 532

Human   553 CAPSNSGADLLCQRLRVHL-PSSIYRLLAPSRDIRMVPEDIKPCCNWDAKKGEYVFPAKKKLQEY 616
            ||||||.:||||:||..|| ...|||::|.|||.|.|||:||||||||..|..:|||:|..|:.|
 Frog   533 CAPSNSASDLLCERLIKHLDQGQIYRIIASSRDFRTVPENIKPCCNWDKDKESFVFPSKHYLKNY 597

Human   617 RVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEV--KETGDPGGQLVLAG 679
            :|:||||:|||||.||.||..||:|:|||||||.:|||.:.||||:::.  .|....||||||||
 Frog   598 KVIITTLVTAGRLASANFPRGHFSHVFIDEAGHAVEPECVTAIAGILDAMDPENNVDGGQLVLAG 662

Human   680 DPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRSHPTILDIPNQ 744
            ||:||||:||||:..:||||.||||||:|.|.||:|..|.|||:|:|||||||||||:||.|||:
 Frog   663 DPKQLGPILRSPIAIEHGLGISLLERLMTQNDLYRKVNDCYDPKFVTKLLRNYRSHPSILKIPNE 727

Human   745 LYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKL 809
            |:|:.||:..||.:..:.:|.|..||::|||||||||.||||||||||||||..|...:..|||.
 Frog   728 LFYDNELKVAADEMASKSYCNWEKLPQKGFPIIFHGVHGKDEREGNSPSFFNVNEIEELLIYLKA 792

Human   810 LLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERS 874
            |.....||..|:::|:.:|:||||||||||||..|..   ||..:..|.:||||||||||||||.
 Frog   793 LFETQGKKCLAKIAPKEIGIISPYRKQVEKIRQAIKS---ELYAVPGIAELKVGSVEEFQGQERK 854

Human   875 VILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCK 939
            |||||||||||.:|:.|..|:||||||||||||||||||||||::|||.:|..||:|..||::|.
 Frog   855 VILISTVRSSQDYVKFDESFSLGFLKNPKRFNVAVTRAKALLILIGNPRILNKDPNWSKFLKYCS 919

Human   940 ENGGYTGCPFPAKLDLQQG-QNLLQGLSKLSPSTSGPHSHDYLPQEREGEGGLSLQVEPEWRNE 1002
            :||..||  ||.:.....| ::||..|....|.          |.:..||..:..|.||:||:|
 Frog   920 DNGSCTG--FPLEDVFDSGIEDLLADLDINDPP----------PGQETGESFIQQQAEPDWRHE 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MOV10	NP_066014.1	DEXXQc_Helz-like	498..733	CDD:350796	156/237 (66%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	126/204 (62%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269|PubMed:22791714	921..965		18/44 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..1003		10/37 (27%)
mov10	XP_002932163.1	P-loop containing Nucleoside Triphosphate Hydrolases	<432..>514	CDD:476819	44/82 (54%)
		DEXXQc_Helz-like	478..716	CDD:350796	156/237 (66%)
		SF1_C_Upf1	717..918	CDD:350195	126/203 (62%)