DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11837 and TFB2M

DIOPT Version :9

Sequence 1:	NP_651660.1	Gene:	CG11837 / 43429	FlyBaseID:	FBgn0039627	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_071761.1	Gene:	TFB2M / 64216	HGNCID:	18559	Length:	396	Species:	Homo sapiens

Alignment Length:	315	Identity:	76/315 - (24%)
Similarity:	117/315 - (37%)	Gaps:	105/315 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DFGQHILKNPLVIT---TMLEKAALRATDVVLEIGPGTGNMTVRMLERAKKVIACEIDTRLAAEL 87
            ||.:::....|..|   ..|.|.: |...::||..||.|.:|..:||...||:|.|.|......|
Human    70 DFKRYVTDRRLAETLAQIYLGKPS-RPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHL 133

  Fly    88 QKRVQATPLQPKLQVLIGDFLKAELP----------------FFDLCIANVPYQISSPL------ 130
            :.  ....|..||:|:..||.|.: |                |.:|.|..||:....||
Human   134 ES--LGKNLDGKLRVIHCDFFKLD-PRSGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVGMF 195

  Fly   131 --------IFKLLLHRPLFRCA---------VLMF--QREFAERLVAKPGD-KLYCRLSINTQLL 175
                    ::||..  .|:.|.         |.||  ::|| ::|:|.||: .||..||:..||.
Human   196 PSRGEKRALWKLAY--DLYSCTSIYKFGRIEVNMFIGEKEF-QKLMADPGNPDLYHVLSVIWQLA 257

  Fly   176 ARVDMLMKVGKNNFRPPPKVESSVVRLEPKNPPPPVNFTEWDGLTRIAFLRKNKTLAATFKVTSV 240
            .                   |..|:.:||        ::.:|..||...|...|.       ..:
Human   258 C-------------------EIKVLHMEP--------WSSFDIYTRKGPLENPKR-------REL 288

  Fly   241 LEMLEKNYKLYRSLRNEPIEDDFKMQDKVISILEEQDMAAKRARSMDIDDFMRLL 295
            |:.|::  |||                 :|.::..|::..|....|:.:.|..||
Human   289 LDQLQQ--KLY-----------------LIQMIPRQNLFTKNLTPMNYNIFFHLL 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11837	NP_651660.1	PTZ00338	16..305	CDD:240367	76/315 (24%)
TFB2M	NP_071761.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..64
		AdoMet_MTases	94..379	CDD:302624	70/290 (24%)
		DNA binding. /evidence=ECO:0000269\|PubMed:29149603, ECO:0007744\|PDB:6ERP, ECO:0007744\|PDB:6ERQ	330..331
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0030
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810