DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkc98E and RPS6KA4

DIOPT Version :10

Sequence 1:NP_524545.2 Gene:Pkc98E / 43428 FlyBaseID:FBgn0003093 Length:739 Species:Drosophila melanogaster
Sequence 2:NP_003933.1 Gene:RPS6KA4 / 8986 HGNCID:10433 Length:772 Species:Homo sapiens


Alignment Length:366 Identity:141/366 - (38%)
Similarity:215/366 - (58%) Gaps:20/366 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   377 NSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKG---TDEIYAIKV 438
            :.|..:.|.:|.:   ..||...  |.|:.:|..:||||.|::|||.|..|.|   ..::||:||
Human     7 DESCAVELRITEA---NLTGHEE--KVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKV 66

  Fly   439 LKKDAIIQDDDV-DCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKAR 502
            |:|.|::|.... :.|.||:.:|.|....|||..||..|||..:|..:::||:||::...:.:.:
Human    67 LRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQ 131

  Fly   503 RFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGM-LTTT 566
            .|:.:....|..|:.|||:.||..|:|||||||:|:|||.|||..|.|||:.||.:.... .|.:
Human   132 YFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFS 196

  Fly   567 FCGTPDYIAPEILKEQE-YGASVDWWALGVLMYEMMAGQPPF----EADNEDELFDSIMHDDVLY 626
            ||||.:|:||||::.:. :|.:||||:||:|::|::.|..||    |.:.:.|:...|:.....:
Human   197 FCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPF 261

  Fly   627 PVWLSREAVSILKGFLTKNPEQRLGCTGDE--NEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNP 689
            |..:...|..:|:..|.|:|::||| .|.:  .|:|.||||..|||..|..|.|..||||::::.
Human   262 PPRIGPVAQDLLQRLLCKDPKKRLG-AGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSE 325

  Fly   690 RDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNP 730
            .|..||..|||:.:||.:|.|:....  :...|.|:|||.|
Human   326 LDVGNFAEEFTRLEPVYSPPGSPPPG--DPRIFQGYSFVAP 364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc98ENP_524545.2 C2_PKC_epsilon 1..134 CDD:175981
C1_nPKC_epsilon-like_rpt1 171..230 CDD:410385
C1_nPKC_epsilon-like_rpt2 250..304 CDD:410388
STKc_nPKC_epsilon 412..729 CDD:270743 131/328 (40%)
RPS6KA4NP_003933.1 STKc_MSK2_N 32..364 CDD:270765 133/334 (40%)
Protein Kinases, catalytic domain 404..714 CDD:473864
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..696
Required for nuclear targeting and association with MAPK14 725..772
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 728..772
Blue background indicates that the domain is not in the aligned region.

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