DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc98E and PKC1

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_009445.2	Gene:	PKC1 / 852169	SGDID:	S000000201	Length:	1151	Species:	Saccharomyces cerevisiae

Alignment Length:	949	Identity:	282/949 - (29%)
Similarity:	417/949 - (43%)	Gaps:	296/949 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DPYVSIDVDESHFDRATTRPKTFDPVWNEQFVHDVTNVSNINLTVF---HDAALPPDDFVANCII 100
            :.||:|.:|::  .:|.|:|...|. |:|.|...|...:.|.:||:   :|:.:|    ||...:
Yeast   234 ESYVTIKIDDT--IKARTKPSRNDR-WSEDFQIPVEKGNEIEITVYDKVNDSLIP----VAIMWL 291

  Fly   101 SFEDLMQ-------SETAVQDLWVN---------------------------------------- 118
            ...|:.:       .:|..|..|||
Yeast   292 LLSDIAEEIRKKKAGQTNEQQGWVNASNINGGSSLASEEGSTLTSTYSNSAIQSTSAKNVQGENT 356

  Fly   119 ------------LEPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNK----EFKERAGFNRRRGAM 167
                        |||.|:|.:                   |:..:|    |.|:..|...|.||:
Yeast   357 STSQISTNSWFVLEPSGQILL-------------------TLGFHKSSQIERKQLMGGLHRHGAI 402

  Fly   168 RRRVHQV---NGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGM 229
            ..|..::   :||.|:.........|::|.:|   :...|:|||.|..:.||||:.:||:||..
Yeast   403 INRKEEIFEQHGHHFVQKSFYNIMCCAYCGDF---LRYTGFQCQDCKFLCHKKCYTNVVTKCIA- 463

  Fly   230 RDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLL-YGLIKQGLQCETCGMNVHKRC 293
                ....:..|...:.|..:||||:..|.:...:|.|||.:| :|..|. .:|..||:..|.:|
Yeast   464 ----KTSTDTDPDEAKLNHRIPHRFLPTSNRGTKWCCHCGYILPWGRHKV-RKCSECGIMCHAQC 523

  Fly   294 QKNVANTCGINTKQMAEIL-----------------------SSLG------ISPDK-------- 321
            ...|.:.||::.:...:||                       ||:|      :||.|
Yeast   524 AHLVPDFCGMSMEMANKILKTIQDTKRNQEKKKRTVPSAQLGSSIGTANGSDLSPSKLAERANAP 588

  Fly   322 --QQPRR--------------------------------------------SKYLN--------- 331
              .|||:                                            ..|||
Yeast   589 LPPQPRKHDKTPSPQKVGRDSPTKQHDPIIDKRISLQTHGREKLNKFIDENEAYLNFTEGAQQTA 653

  Fly   332 ---------------------------------------------------------QQGGE--- 336
                                                                     |..||
Yeast   654 EFSSPEKTLDPTSNRRSLGLTDLSIEHSQTWESKDDLMRDELELWKAQREEMELEIKQDSGEIQE 718

  Fly   337 ----DNYGASLGADGDGAPGQSFRSCALSVDSLATS--------TTTMTSGYNSSSCM----SLA 385
                |:.........|......||...|::||..|:        |..:...:.|...:    |||
Yeast   719 DLEVDHIDLETKQKLDWENKNDFREADLTIDSTHTNPFRDMNSETFQIEQDHASKEVLQETVSLA 783

  Fly   386 VTGSGGVGATGETRP------------------GKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDE 432
            .|.:.....|.:..|                  .|.||.:|..:||||||:||||:|::.|.||.
Yeast   784 PTSTHASRTTDQQSPQKSQTSTSAKHKKRAAKRRKVSLDNFVLLKVLGKGNFGKVILSKSKNTDR 848

  Fly   433 IYAIKVLKKDAIIQDDDVDCTMTEKRILALA--ANHPFLTALHSCFQTPDRLFFVMEYVNGGDLM 495
            :.||||||||.|||:.|::....||::..||  ..|||||.|:..|||.:|::|.||::.|||||
Yeast   849 LCAIKVLKKDNIIQNHDIESARAEKKVFLLATKTKHPFLTNLYCSFQTENRIYFAMEFIGGGDLM 913

  Fly   496 FQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMN 560
            :.:|. :|....||.||||||.|||::.|.:|||||||||:||||..|||.|:||:|:||:.:..
Yeast   914 WHVQN-QRLSVRRAKFYAAEVLLALKYFHDNGVIYRDLKLENILLTPEGHIKIADYGLCKDEMWY 977

  Fly   561 GMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVL 625
            |..|:||||||:::||||||||||..:|||||.|||:|:|:..|.||..|:|||:|::|:.|:.|
Yeast   978 GNRTSTFCGTPEFMAPEILKEQEYTKAVDWWAFGVLLYQMLLCQSPFSGDDEDEVFNAILTDEPL 1042

  Fly   626 YPVWLSREAVSILKGFLTKNPEQRLGC-TGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNP 689
            ||:.::.|.|.|.:|.|||:||:|||. ..|.:|:.:.|||..:::.::....:|||:.|::|:|
Yeast  1043 YPIDMAGEIVQIFQGLLTKDPEKRLGAGPRDADEVMEEPFFRNINFDDILNLRVKPPYIPEIKSP 1107

  Fly   690 RDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFV 728
            .|.:.|:.|||...|.|||:.: |:....|:||.||||:
Yeast  1108 EDTSYFEQEFTSAPPTLTPLPS-VLTTSQQEEFRGFSFM 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	30/156 (19%)
		C1_1	177..228	CDD:278556	18/50 (36%)
		C1_1	252..304	CDD:278556	19/52 (37%)
		STKc_nPKC_epsilon	412..729	CDD:270743	165/320 (52%)
PKC1	NP_009445.2	HR1_PKC-like_1_fungi	1..72	CDD:212011
		HR1_PKC-like_2_fungi	110..181	CDD:212010
		C2_fungal_Pkc1p	211..319	CDD:176071	25/91 (27%)
		C1_ScPKC1-like_rpt1	413..464	CDD:410372	19/58 (33%)
		C1_ScPKC1-like_rpt2	478..536	CDD:410373	20/58 (34%)
		STKc_PKC	828..1145	CDD:270722	164/318 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345380
Domainoid	1	1.000	296	1.000	Domainoid score	I225
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48343
Inparanoid	1	1.050	438	1.000	Inparanoid score	I264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		otm46471
orthoMCL	1	0.900	-	-		OOG6_102972
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
TreeFam	0	0.000	Not matched by this tool.
	13	12.820