Protein Alignment Pkc98E and Prkci

DIOPT Version :9

• Sequence 1: NP_001287577.1
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_114448.1
• Gene: Prkci / 84006
• RGDID: 620961
• Length: 596
• Species: Rattus norvegicus
• Alignment Length: 587
• Identity: 233/587 - (39%)
• Similarity: 311/587 - (52%)
• Gaps: 144/587 - (24%)

  Fly   163 RRGAMR-RRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKC 226
            ||||.| |:::..|||.|.|....:...|:.|.:.|||:|:|||:|..|.|:||||||..|..:|
  Rat   126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIEC 190

  Fly   227 PGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHK 291
            .  |...|.: .|:|..|
  Rat   191 G--RHSLPPE-PMMPMDQ----------------------------------------------- 205

  Fly   292 RCQKNVANTCGINTKQMAEILSSLGISPDKQQ------PRRSKYLNQQGGEDNYGASLGADGDGA 350
                                 ||:  .||..|      |...:.|:|.|.|..
  Rat   206 ---------------------SSM--HPDHTQTVIPYNPSSHESLDQVGEEKE------------ 235

  Fly   351 PGQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLG 415
                             :..|..||..|||                      ..|.||:.::|:|
  Rat   236 -----------------AMNTRESGKASSS----------------------LGLQDFDLLRVIG 261

  Fly   416 KGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPD 480
            :||:.||:|...|.||.|||:||:||:.:..|:|:|...|||.:...|:|||||..|||||||..
  Rat   262 RGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTES 326

  Fly   481 RLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGH 545
            |||||:||||||||||.:|:.|:.....|.||:||::|||.:||..|:|||||||||:|||.|||
  Rat   327 RLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGH 391

  Fly   546 CKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFE-- 608
            .||.|:||||||:..|..|:||||||:|||||||:.::||.|||||||||||:|||||:.||:
  Rat   392 IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIV 456

  Fly   609 --ADN-----EDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC---TGDENEIRKHP 663
              :||     ||.||..|:...:..|..||.:|.|:||.||.|:|::||||   ||.. :|:.||
  Rat   457 GSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFA-DIQGHP 520

  Fly   664 FFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFV 728
            ||..:||..:|::.:.|||:|.:......:|||::||.|...|||..:::||.|:|.||.||.::
  Rat   521 FFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYI 585

  Fly   729 NP 730
            ||
  Rat   586 NP 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556	23/50 (46%)
		C1_1	252..304	CDD:278556	0/51 (0%)
		STKc_nPKC_epsilon	412..729	CDD:270743	176/328 (54%)
Prkci	NP_114448.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Regulatory domain. /evidence=ECO:0000250	2..253		53/250 (21%)
		Required for interaction with RAB2. /evidence=ECO:0000250	2..28
		PB1_aPKC	26..108	CDD:99725
		Interaction with PARD6A. /evidence=ECO:0000250	72..91
		Pseudosubstrate. /evidence=ECO:0000250	125..134		5/7 (71%)
		C1_aPKC	139..193	CDD:410344	25/55 (45%)
		STKc_aPKC_iota	233..596	CDD:270769	188/407 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910