Protein Alignment Pkc98E and Prkch

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_112347.1
• Gene: Prkch / 81749
• RGDID: 621888
• Length: 683
• Species: Rattus norvegicus
• Alignment Length: 746
• Identity: 395/746 - (52%)
• Similarity: 511/746 - (68%)
• Gaps: 83/746 - (11%)

  Fly     2 FTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWN 66
            |.|.|::::.||.||:||.:..||:| |.|  ..||:|||:::.||:....:.:|:.||..|.:|
  Rat     8 FNGYLRVRIGEAVGLQPTRWSLRHSL-FKK--GHQLLDPYLTVSVDQVRVGQTSTKQKTNKPTYN 69

  Fly    67 EQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQ----SETAVQDLWVNLEPQGKIHV 127
            |:|..:|::..::.|.|||:..|..|.|||||.:.|::|::    |:|.  :.||:|||:||:.|
  Rat    70 EEFCTNVSDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTAGTSDTF--EGWVDLEPEGKVFV 132

  Fly   128 IIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRR-GAMRRRVHQVNGHKFMATFLRQPTFCS 191
            :|.|..        :..|.|:..::.||.   |.|:| .|||||||||||||||||:|||||:||
  Rat   133 VITLTG--------SFTEATLQRDRIFKH---FTRKRQRAMRRRVHQVNGHKFMATYLRQPTYCS 186

  Fly   192 HCREFIWGI-GKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFV 255
            ||||||||: |||||||||||.||||:||..:|:.|....:..  ||:...|.|||.:|:||:|.
  Rat   187 HCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNIN--KVDAKIAEQRFGINIPHKFN 249

  Fly   256 VHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPD 320
            ||:||..||||||||||:|:::|||||:.|.||||.|||.|||..||:|..::|:.|:.:|:.|.
  Rat   250 VHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPG 314

  Fly   321 KQQPRRSKY-----LNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSS 380
            ...| .||.     |.:||.|.:      .:|:|.                        |.||||
  Rat   315 NISP-TSKLISRSTLRRQGKEGS------KEGNGI------------------------GVNSSS 348

  Fly   381 CMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAII 445
                                 :..:.:|.||:|||||||||||||..|.|.|:||:||||||.|:
  Rat   349 ---------------------RFGIDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVIL 392

  Fly   446 QDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAA 510
            |||||:|||||||||:||.||||||.|..|||||||||||||:||||||||.|||:|||:.:||.
  Rat   393 QDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARAR 457

  Fly   511 FYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIA 575
            |||||:..||.|||..|:|||||||||:|||.||||||||||||||||.||:.|.||||||||||
  Rat   458 FYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIA 522

  Fly   576 PEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKG 640
            ||||:|..||.:|||||:|||:|||:.|..||||:|||:||::|::|:|:||.||..:|..|||.
  Rat   523 PEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKS 587

  Fly   641 FLTKNPEQRLG--CTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKED 703
            |:||||..|||  ..|.|:||.:||||.::||.:|..|.::|||||::|:..|.:|||.:|.||:
  Rat   588 FMTKNPTMRLGSLTQGGEHEILRHPFFKEIDWVQLNHRQLEPPFRPRIKSREDVSNFDPDFIKEE 652

  Fly   704 PVLTPIGNEVVRCINQDEFAGFSFVNPKFGP 734
            ||||||....:..||||||..||:|:|:..|
  Rat   653 PVLTPIDEGHLPMINQDEFRNFSYVSPELQP 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	54/135 (40%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	46/59 (78%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	36/53 (68%)
		STKc_nPKC_epsilon	412..729	CDD:270743	215/318 (68%)
Prkch	NP_112347.1	C2_PKC_epsilon	8..140	CDD:175981	54/144 (38%)
		C1_nPKC_epsilon-like_rpt1	166..226	CDD:410385	46/59 (78%)
		C1_nPKC_epsilon-like_rpt2	244..298	CDD:410388	36/53 (68%)
		STKc_nPKC_eta	359..681	CDD:270742	217/321 (68%)