Protein Alignment Pkc98E and prkca

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: XP_031750036.1
• Gene: prkca / 780209
• XenbaseID: XB-GENE-5942870
• Length: 692
• Species: Xenopus tropicalis
• Alignment Length: 680
• Identity: 310/680 - (45%)
• Similarity: 399/680 - (58%)
• Gaps: 132/680 - (19%)

  Fly   163 RRGAMRRR-VHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKC 226
            |:||:|:: ||:|..|||:|.|.:||||||||.:||||.||||:|||||..||||:||..|...|
 Frog    26 RKGALRQKNVHEVKNHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFTC 90

  Fly   227 PGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHK 291
            || .|:.|...:  |..:       |:|.:|:|...||||||||||||||.||::||||.|||||
 Frog    91 PG-ADKGPDTDD--PRSK-------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCETCDMNVHK 145

  Fly   292 RCQKNVANTCGIN---------------------------------------------------- 304
            .|..||.:.||::
 Frog   146 VCVINVPSLCGMDHTEKRGRIYLKAEVKGDVLNVIVRDAKNLIPMDPNGLSDPYVKLKLIPDPKN 210

  Fly   305 -----TKQMAEILS---------------------------------------SLGISPDKQQPR 325
                 ||.....|:                                       |.|:|...:.|.
 Frog   211 ESKKKTKTFRSTLNPQWNECFTFKLKPTDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPA 275

  Fly   326 RS--KYLNQQGGEDNYGASLGA---DGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLA 385
            ..  |.|||:.|| .|...:..   ||:....|.|.....:.|.:......          ..|.
 Frog   276 CGWYKLLNQEEGE-YYNVPIPEEEDDGNIELRQKFEGTVPARDKVVPPVQK----------AKLG 329

  Fly   386 VTGSGGVGATGETRP-------GKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDA 443
            ..|:..:..|.|.||       ....|.||:|:.||||||||||||||:||.||::|||:||||.
 Frog   330 PAGNKVISPTDERRPYVPSNNIDSVRLTDFSFLMVLGKGSFGKVMLAERKGADELFAIKILKKDV 394

  Fly   444 IIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASR 508
            :||||||:|||.|||:|||....||||.|||||||.|||:||||||||||||:.||:..:|:..:
 Frog   395 VIQDDDVECTMVEKRVLALQGKPPFLTHLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQ 459

  Fly   509 AAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDY 573
            |.|||||:::.|.|||..|::||||||||::||.|||.|:||||||||.:::|:.|.||||||||
 Frog   460 AVFYAAEISVGLFFLHKKGIVYRDLKLDNVMLDSEGHIKIADFGMCKEHMVDGVTTRTFCGTPDY 524

  Fly   574 IAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSIL 638
            |||||:..|.||.||||||.|||:|||:||||||:.::|||||.|||..:|.||..:|:|||||.
 Frog   525 IAPEIIAYQPYGRSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSMSKEAVSIC 589

  Fly   639 KGFLTKNPEQRLGCTGD-ENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKE 702
            ||.:||:|.:||||..: |.:||:|.||.::||::|:.|.|:|||:||:.. :.|.|||..||:.
 Frog   590 KGLMTKHPVKRLGCGPEGERDIREHTFFRRIDWEKLQNREIQPPFKPKVCG-KGAENFDKFFTRG 653

  Fly   703 DPVLTPIGNEVVRCINQDEFAGFSFVNPKF 732
            .|||||....|:..|:|.:|.|||::||:|
 Frog   654 QPVLTPPDQLVIANIDQADFEGFSYINPQF 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	39/58 (67%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	34/53 (64%)
		STKc_nPKC_epsilon	412..729	CDD:270743	198/317 (62%)
prkca	XP_031750036.1	C1_cPKC_rpt1	39..96	CDD:410383	37/57 (65%)
		C1_cPKC_rpt2	106..159	CDD:410386	34/52 (65%)
		C2_PKC_alpha_gamma	163..293	CDD:175992	14/130 (11%)
		STKc_cPKC_alpha	348..688	CDD:270766	205/337 (61%)