DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and prkcd

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_002934267.1	Gene:	prkcd / 733756	XenbaseID:	XB-GENE-478663	Length:	683	Species:	Xenopus tropicalis

Alignment Length:	701	Identity:	301/701 - (42%)
Similarity:	422/701 - (60%)	Gaps:	59/701 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PYVSIDVDES-HFDRATT---RPKTFDPVWNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCII 100
            |:.::.|.|| ..:|..|   :..|..|.|...|...:.....|.:.:...|..|..:......:
Frog    26 PFCAVKVKESLTTERGKTLVQKKPTMYPDWKSPFDAHIYEGRVIQIVLMKAAEDPLSEATVGVSV 90

  Fly   101 SFEDLMQSETAVQDLWVNLEPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRG 165
            ..|...:. ....:.|::|:||.|  |::.::...:.|..::.|       :|.:.....|||||
Frog    91 LAERCKKG-NGKSEFWLDLQPQAK--VLMSVQYFLEDADLKSSV-------REDEGLVTINRRRG 145

  Fly   166 AMRR-RVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPG- 228
            |::: ::|.:..|:|:|||..||||||.||:|:||:.||||:|:.|...:||||...::.:|.|
Frog   146 AIKQAKIHYIKNHEFIATFFGQPTFCSVCRDFVWGLNKQGYKCRQCNAAIHKKCIEMIIGRCTGT 210

  Fly   229 ---MRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVH 290
               .||....|       :|||:::||||.|::||..||||||||||:||:||||:|:.|.||||
Frog   211 AANSRDTMFQK-------ERFNIDMPHRFKVYNYKSPTFCDHCGSLLWGLVKQGLKCDECAMNVH 268

  Fly   291 KRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSF 355
            .:||..|||.||||.|.:||.|:.:.:   |...|:|     ..|.||.....|.: ...||...
Frog   269 HKCQNKVANLCGINQKLLAEALNQVSM---KSSSRKS-----DSGLDNIAIYQGVN-PKTPGLPM 324

  Fly   356 RSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFG 420
                  .|:.......:..|.:....:||:               .:..:.:|.|.|||||||||
Frog   325 ------PDATDNQYDRLWEGSSPHPHISLS---------------SRLKIDNFVFHKVLGKGSFG 368

  Fly   421 KVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFV 485
            ||:|||.||..|.:|||.||||.::.||||:|||.|||:||||..:||||.::..|||.:.||||
Frog   369 KVLLAELKGKGEYFAIKALKKDVVLIDDDVECTMVEKRVLALAWENPFLTHIYCSFQTKEHLFFV 433

  Fly   486 MEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLAD 550
            ||::|||||||.||...||:..||.|||:|:...|||||:.|:|||||||||::||::||.|:||
Frog   434 MEFLNGGDLMFHIQDKGRFDLYRATFYASEIICGLQFLHSKGIIYRDLKLDNVMLDKDGHIKIAD 498

  Fly   551 FGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDEL 615
            ||||||.:......:||||||||||||||:..:|..|||||:.|||:|||:.||.||..|:||||
Frog   499 FGMCKENVYGDNKASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDEL 563

  Fly   616 FDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDENEIRKHPFFAKLDWKELEKRNIKP 680
            |:||..|...||.|:::|:..||:....:.|.:|||..|:   |:.||||..::|..||:|.::|
Frog   564 FESIRQDTPHYPRWITKESKDILERLFEREPTKRLGVVGN---IKVHPFFKTINWTALERRELEP 625

  Fly   681 PFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPK 731
            ||:||:|:|.|.:|||.||..|.|.|:.....::..::|..|.||||:|||
Frog   626 PFKPKVKSPSDYSNFDREFLSEKPRLSFSDKNLIDSMDQSAFHGFSFINPK 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	20/97 (21%)
		C1_1	177..228	CDD:278556	27/50 (54%)
		C1_1	252..304	CDD:278556	35/51 (69%)
		STKc_nPKC_epsilon	412..729	CDD:270743	177/316 (56%)
prkcd	XP_002934267.1	C1_1	158..207	CDD:365894	26/48 (54%)
		C1_1	230..280	CDD:365894	33/49 (67%)
		STKc_nPKC_delta	360..675	CDD:173710	177/317 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950