DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and sgk3

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001103937.1	Gene:	sgk3 / 564523	ZFINID:	ZDB-GENE-070424-62	Length:	486	Species:	Danio rerio

Alignment Length:	346	Identity:	156/346 - (45%)
Similarity:	223/346 - (64%)	Gaps:	11/346 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 GVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMT 455
            |..|....:|     .||:|:||:||||||||:||::|...:.||||||:|..|:...:....|.
Zfish   140 GPSANPHAKP-----TDFDFLKVIGKGSFGKVLLAKRKRDGKCYAIKVLQKKVILNRREQKHIMA 199

  Fly   456 EKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLAL 520
            |:.:|.....||||..||..|||.|:|:||:::||||:|.|.:||.|.|...||.||.||:..||
Zfish   200 ERNVLLKNVKHPFLVGLHYSFQTTDKLYFVLDFVNGGELFFHLQKERTFPEPRAKFYIAEMASAL 264

  Fly   521 QFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYG 585
            .:||:..::|||||.:|||||.:||..|.|||:|||||.....||||||||:|:|||:|::|.|.
Zfish   265 GYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKEGISQADTTTTFCGTPEYLAPEVLRKQPYD 329

  Fly   586 ASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRL 650
            .:||||.||.::|||:.|.|||.:.:..|::|:|:|.:::.....|..|.|||:..|.|:..:||
Zfish   330 NTVDWWCLGSVLYEMLYGLPPFYSRDTHEMYDNILHKELVMRPGASTAAWSILQTLLEKDHTRRL 394

  Fly   651 GCTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKE---DPVLTPIGNE 712
            |...|.||:::|.||:.::|.:||::.:.|||.|.:::..|.:|||.|||:|   :.|....|..
Zfish   395 GYRDDFNEVKEHEFFSSINWYDLEQKKLPPPFNPSVESQYDISNFDPEFTEETVPNSVCFSSGPS 459

  Fly   713 VVRCI---NQDEFAGFSFVNP 730
            :|...   ..|.|.|||:..|
Zfish   460 IVNASVMEADDAFLGFSYAPP 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556
		C1_1	252..304	CDD:278556
		STKc_nPKC_epsilon	412..729	CDD:270743	149/322 (46%)
sgk3	NP_001103937.1	PX_CISK	6..114	CDD:132780
		S_TKc	152..409	CDD:214567	126/256 (49%)
		STKc_SGK3	155..480	CDD:270755	149/324 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910