DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and pkn1a

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_005160107.3	Gene:	pkn1a / 560840	ZFINID:	ZDB-GENE-061207-17	Length:	967	Species:	Danio rerio

Alignment Length:	678	Identity:	219/678 - (32%)
Similarity:	319/678 - (47%)	Gaps:	173/678 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 WNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISF---EDLMQSETAVQDLWVNLEPQGKIH 126
            |::.|:.::.....:.:.|:.      .|:.:.|.:.|   ||.:.::.  ..:.:.|||||.:.
Zfish   447 WDQTFIIELERSREMEIAVYW------RDYRSLCALKFLKLEDFLDNQK--HKVQLELEPQGLLL 503

  Fly   127 VIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCS 191
            ..:...|        .|:|.   |.:..:::..|::::|....|..|:|..  :.||:|.
Zfish   504 AEVTFFN--------PVIER---VPRLKRQKNVFSKQQGKAFLRARQMNVD--IGTFVRL----- 550

  Fly   192 HCREFIWGIGKQG-YQCQVCTL----VVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLP 251
             .|..|..:...| |.....||    :..:|..|..         :.|.||::
Zfish   551 -LRNAIPTVNNTGTYSPNAHTLQTGEISVEKLSLDF---------DSPMKVDI------------ 593

  Fly   252 HRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLG 316
                                                      ::.|.:
Zfish   594 ------------------------------------------RREVTD----------------- 599

  Fly   317 ISPDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSL-ATSTTTMTSGYNSSS 380
            ||..::||                                    |.:.| |...||....::.||
Zfish   600 ISTPERQP------------------------------------STEPLSAPDVTTPIRTHSLSS 628

  Fly   381 CMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAII 445
                            :.:....||.||..|.|||:|.||||:|||.|.:..:||||.|||..|:
Zfish   629 ----------------KQKKTSLSLQDFRLIAVLGRGHFGKVLLAEYKKSGSMYAIKALKKGDIV 677

  Fly   446 QDDDVDCTMTEKRILAL--AANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASR 508
            ..|:|:..|.||||...  .|.||||..|.:|||||:.:.|||||..|||||..|. |..|...|
Zfish   678 ARDEVESLMCEKRIFEAVNGAQHPFLVNLFACFQTPEHVCFVMEYTAGGDLMMHIH-ADVFTEPR 741

  Fly   509 AAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDY 573
            |.||:|.|.|.|||||.:.::||||||||:|||.||:.|:||||:||||:..|..|:||||||::
Zfish   742 AVFYSACVVLGLQFLHDNKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTSTFCGTPEF 806

  Fly   574 IAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSIL 638
            :|||:|.:..|..:||||.||||:|||:.|:.||..|:|:|:||||::|:|.||.:||.||:.|:
Zfish   807 LAPEVLTDTSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIM 871

  Fly   639 KGFLTKNPEQRLGCT-GDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKE 702
            :..|.:|||:|||.: .|..:::|.|||..:||:.|..|.:.|||.|.:....|.:|||.|||.|
Zfish   872 RRLLRRNPERRLGSSEKDAEDVKKQPFFRNMDWEALLLRKLPPPFIPSIGGKEDVSNFDEEFTTE 936

  Fly   703 DPVLTPIGN-EVVRCINQDEFAGFSFVN 729
            .|.|||... .|:...:||.|..|.:|:
Zfish   937 APTLTPPREPRVLSRKDQDSFRDFDYVS 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	13/71 (18%)
		C1_1	177..228	CDD:278556	11/55 (20%)
		C1_1	252..304	CDD:278556	1/51 (2%)
		STKc_nPKC_epsilon	412..729	CDD:270743	165/320 (52%)
pkn1a	XP_005160107.3	HR1_PKN_1	71..136	CDD:212012
		HR1_PKN1_2	156..233	CDD:212020
		HR1	237..310	CDD:320753
		C2	421..508	CDD:326325	13/68 (19%)
		STKc_PKN	640..965	CDD:270741	168/326 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840