Protein Alignment Pkc98E and PRKG1

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_006249.1
• Gene: PRKG1 / 5592
• HGNCID: 9414
• Length: 686
• Species: Homo sapiens
• Alignment Length: 710
• Identity: 182/710 - (25%)
• Similarity: 300/710 - (42%)
• Gaps: 158/710 - (22%)

  Fly   103 EDLMQSETAVQDLWVNLEPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAM 167
            |:|.|.:..:.:|  .||...|..:|.:|:|..||.:  :|:.  .|..:..|:.|  :..:|..
Human    16 EELRQRDALIDEL--ELELDQKDELIQKLQNELDKYR--SVIR--PATQQAQKQSA--STLQGEP 72

  Fly   168 RRRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDE 232
            |.:...::.         :||               .:..|..:.|.     |....|.|..:|
Human    73 RTKRQAISA---------EPT---------------AFDIQDLSHVT-----LPFYPKSPQSKD- 107

  Fly   233 QPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFC--------DHC-------GSLLY-------GL 275
               .::.......|..||.    :...:....|        |.|       |||:|       .:
Human   108 ---LIKEAILDNDFMKNLE----LSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEV 165

  Fly   276 IKQGLQCETCG-----------------------MNV-----HKRCQKNVANTCGI--NTKQM-- 308
            .|:|::..|.|                       :||     .::|.:.:....|:  :|:.|
Human   166 TKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEF 230

  Fly   309 -----------AEILSSLGISPDKQQPRRSKYLNQQG--GEDNYGASLG---ADGDGAP------ 351
                       .||||.|....::......:|:.:||  |:..:..|.|   ...:.:|
Human   231 LKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVF 295

  Fly   352 ------GQSFRSCALSVDSLATSTTTMTSGYNSSSCMSL-------AVTGSGGVGATG-ETRPGK 402
                  |..|...||..:.:.|:.....   .:.:|:.:       .:.|...|.... |....|
Human   296 LRTLGKGDWFGEKALQGEDVRTANVIAA---EAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAK 357

  Fly   403 C------------SLLDFNFIKVLGKGSFGKVMLAEKKGTD-EIYAIKVLKKDAIIQDDDVDCTM 454
            .            .|.|||.|..||.|.||:|.|.:.|..: :.:|:|:|||..|:.....:...
Human   358 AKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIR 422

  Fly   455 TEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLA 519
            :||:|:. .|:..|:..|:..|:....|:.:||...||:|...::....||.|...||.|.|..|
Human   423 SEKQIMQ-GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEA 486

  Fly   520 LQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEY 584
            ..:||:.|:||||||.:|::||..|:.||.|||..|: |..|..|.||||||:|:||||:..:.:
Human   487 FAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKGH 550

  Fly   585 GASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMH--DDVLYPVWLSREAVSILKGFLTKNPE 647
            ..|.|:|:||:||||::.|.|||...:..:.::.|:.  |.:.:|..:::.|.:::|.....||.
Human   551 DISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS 615

  Fly   648 QRLG-CTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDA--EFTKEDP 704
            :||| ......:|:||.:|...:|:.|.|..:.||..|.:.:|.|.:|||:  |...|.|
Human   616 ERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPP 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	9/30 (30%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	7/58 (12%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	16/105 (15%)
		STKc_nPKC_epsilon	412..729	CDD:270743	109/299 (36%)
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375	13/44 (30%)
		CAP_ED	118..227	CDD:237999	19/112 (17%)
		CAP_ED	237..341	CDD:237999	18/106 (17%)
		STKc_cGK	381..641	CDD:270724	96/261 (37%)
		S_TK_X	636..>679	CDD:214529	14/40 (35%)