DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and PRKCQ

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_005252553.1	Gene:	PRKCQ / 5588	HGNCID:	9410	Length:	740	Species:	Homo sapiens

Alignment Length:	741	Identity:	308/741 - (41%)
Similarity:	427/741 - (57%)	Gaps:	96/741 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QLIDPYVSIDVDE----SHFDRATTRPKTFDPVWNEQFVHDVTN-------VSNINLTVFHDAAL 89
            :.::||.::.|.|    .:......:..|..|.|:..|...:..       |...|:.:..:..:
Human    57 EAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTV 121

  Fly    90 PPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKI----HVIIELKNRTDKAKAEAVVEHTVAV 150
            .        :.|..:..:......::|:.|:|||::    ...:|:.:..|.
Human   122 E--------LYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDM------------- 165

  Fly   151 NKEFKERAGF---NRRRGAMRR-RVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCT 211
             .|| |..||   ::||||::: :||.|..|:|.|||..||||||.|.||:||:.||||||:.|.
Human   166 -NEF-ETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCN 228

  Fly   212 LVVHKKCHLSVVSKCPG----MRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLL 272
            ..:||||...|::||.|    .|:....|       :||.:::||||.|::||..|||:|||:||
Human   229 AAIHKKCIDKVIAKCTGSAINSRETMFHK-------ERFKIDMPHRFKVYNYKSPTFCEHCGTLL 286

  Fly   273 YGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGED 337
            :||.:|||:|:.||||||.|||..|||.||||.|.|||.|:.:..:...:..|.::.:.::|..:
Human   287 WGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVE 351

  Fly   338 NYGASLGADGDGAP------------GQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSG 390
             .|.......:..|            |.|:.|....||.:......
Human   352 -IGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLPEP------------------- 396

  Fly   391 GVGATGETRPG---KCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDC 452
               ...:.||.   |..:.||...|:|||||||||.|||.|.|::.:|||.||||.::.||||:|
Human   397 ---ELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVEC 458

  Fly   453 TMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVT 517
            ||.|||:|:||..|||||.:...|||.:.|||||||:||||||:.||...:|:.|||.|||||:.
Human   459 TMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEII 523

  Fly   518 LALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQ 582
            |.|||||:.|::||||||||||||::||.|:||||||||.::....|.||||||||||||||..|
Human   524 LGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQ 588

  Fly   583 EYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPE 647
            :|..|||||:.|||:|||:.||.||...:|:|||.||..|:..||.||.:||..:|.....:.||
Human   589 KYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPE 653

  Fly   648 QRLGCTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNE 712
            :|||..||   ||:||.|.:::|:|||::.|.||||||:|:|.|.:|||.||..|.|.|:.....
Human   654 KRLGVRGD---IRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRA 715

  Fly   713 VVRCINQDEFAGFSFVNPKFGPERKV 738
            ::..::|:.|..|||:||  |.||.:
Human   716 LINSMDQNMFRNFSFMNP--GMERLI 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	17/112 (15%)
		C1_1	177..228	CDD:278556	30/50 (60%)
		C1_1	252..304	CDD:278556	34/51 (67%)
		STKc_nPKC_epsilon	412..729	CDD:270743	182/316 (58%)
PRKCQ	XP_005252553.1	C1_1	194..246	CDD:278556	30/51 (59%)
		C1_1	266..318	CDD:278556	34/51 (67%)
		STKc_nPKC_theta	408..738	CDD:270770	189/334 (57%)
		S_TKc	414..668	CDD:214567	155/256 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7687
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850