DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkc98E and PKN2

DIOPT Version :9

Sequence 1:NP_001287577.1 Gene:Pkc98E / 43428 FlyBaseID:FBgn0003093 Length:739 Species:Drosophila melanogaster
Sequence 2:NP_006247.1 Gene:PKN2 / 5586 HGNCID:9406 Length:984 Species:Homo sapiens


Alignment Length:702 Identity:229/702 - (32%)
Similarity:330/702 - (47%) Gaps:146/702 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 DRATTRPKTFDPV----WNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISF---EDLMQSE 109
            |.......::.|:    |:::|..::.....:.::|:.      .|:.:.|.:.|   ||.:.::
Human   400 DNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYW------RDWRSLCAVKFLRLEDFLDNQ 458

  Fly   110 TAVQDLWVNLEPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMRRRVHQV 174
            .  ..:.:.|||||.:...:...|        .|:|....:.::.|.   |::::|         
Human   459 R--HGMCLYLEPQGTLFAEVTFFN--------PVIERRPKLQRQKKI---FSKQQG--------- 501

  Fly   175 NGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVS-KCPGMRDEQPAKVE 238
                  .||||.|..  :.....||        ::....:....|....| :.|     .|..|.
Human   502 ------KTFLRAPQM--NINIATWG--------RLVRRAIPTVNHSGTFSPQAP-----VPTTVP 545

  Fly   239 MVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGI 303
            :|      :|.:|......|....|..|.                                    
Human   546 VV------DVRIPQLAPPASDSTVTKLDF------------------------------------ 568

  Fly   304 NTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASL------GADGDGA-PGQSFRSCALS 361
                      .|...|....||.|..     ||.:..:.|      |.|.:.. ..|:.|:..|.
Human   569 ----------DLEPEPPPAPPRASSL-----GEIDESSELRVLDIPGQDSETVFDIQNDRNSILP 618

  Fly   362 VDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPG----KCSLLDFNFIKVLGKGSFGKV 422
            .........|..||...|....|            |.|..    :.:|.||....|||:|.||||
Human   619 KSQSEYKPDTPQSGLEYSGIQEL------------EDRRSQQRFQFNLQDFRCCAVLGRGHFGKV 671

  Fly   423 MLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILAL--AANHPFLTALHSCFQTPDRLFFV 485
            :|||.|.|:|::|||.|||..|:..|:||..|.||||...  :..||||..|.:||||.:.:.||
Human   672 LLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFV 736

  Fly   486 MEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLAD 550
            |||..|||||..|. ...|...||.||||.|.|.||:||.|.::||||||||:|||.||..|:||
Human   737 MEYAAGGDLMMHIH-TDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIAD 800

  Fly   551 FGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDEL 615
            ||:||||:..|..|:||||||:::|||:|.|..|..:||||.||||:|||:.|:.||..|:|:|:
Human   801 FGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEV 865

  Fly   616 FDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCT-GDENEIRKHPFFAKLDWKELEKRNIK 679
            ||||::|:|.||.:||.||:||::..|.:|||:|||.: .|..:::|||||..:||..|..:.:|
Human   866 FDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVK 930

  Fly   680 PPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDE---FAGFSFV 728
            |||.|.::...|.:|||.|||.|.|:|||  ....|.::::|   |..|.::
Human   931 PPFIPTIRGREDVSNFDDEFTSEAPILTP--PREPRILSEEEQEMFRDFDYI 980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc98ENP_001287577.1 C2_PKC_epsilon 1..134 CDD:175981 15/88 (17%)
C1_1 177..228 CDD:278556 9/51 (18%)
C1_1 252..304 CDD:278556 3/51 (6%)
STKc_nPKC_epsilon 412..729 CDD:270743 167/323 (52%)
PKN2NP_006247.1 HR1_PKN_1 42..107 CDD:212012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..133
HR1 130..201 CDD:294066
HR1_PKN2_3 209..282 CDD:212025
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 351..383
Necessary to rescue apical junction formation. /evidence=ECO:0000250 382..463 10/70 (14%)
C2_PKN-like 390..473 CDD:176069 15/80 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 558..584 8/71 (11%)
STKc_PKN 657..982 CDD:270741 168/327 (51%)
S_TKc 662..916 CDD:214567 141/254 (56%)
Necessary for the catalytic activity 917..977 23/61 (38%)
Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA 978..984 0/3 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0694
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R891
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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