Protein Alignment Pkc98E and PKN1

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_998725.1
• Gene: PKN1 / 5585
• HGNCID: 9405
• Length: 948
• Species: Homo sapiens
• Alignment Length: 671
• Identity: 221/671 - (32%)
• Similarity: 318/671 - (47%)
• Gaps: 154/671 - (22%)

  Fly    65 WNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISF---EDLMQSETAVQDLWVNLEPQGKIH 126
            |::.|..::.....:.|.||.      .|....|.:.|   ||.:.:|.  .::.:::||||.:.
Human   421 WDQSFTLELERARELELAVFW------RDQRGLCALKFLKLEDFLDNER--HEVQLDMEPQGCLV 477

  Fly   127 VIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCS 191
            ..:..:|        .|:|....:.::.|.   |::::|...:|..|:|..  :||::|
Human   478 AEVTFRN--------PVIERIPRLRRQKKI---FSKQQGKAFQRARQMNID--VATWVR------ 523

  Fly   192 HCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVV 256
                                                                      |..|.:.
Human   524 ----------------------------------------------------------LLRRLIP 530

  Fly   257 HSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK 321
            ::....||....        ..|.:..|.|                             .||.:|
Human   531 NATGTGTFSPGA--------SPGSEARTTG-----------------------------DISVEK 558

  Fly   322 QQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAV 386
                    ||           ||.|.|.:|.:|.|....|..||::.....|:....|....
Human   559 --------LN-----------LGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQE--- 601

  Fly   387 TGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVD 451
              :.|.......|....:|.||.|:.|||:|.||||:|:|.:.:.|::|||.|||..|:..|:|:
Human   602 --TPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVE 664

  Fly   452 CTMTEKRILA--LAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAA 514
            ..|.||||||  .:|.||||..|..|||||:.:.|||||..|||||..|. :..|...||.||:|
Human   665 SLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH-SDVFSEPRAIFYSA 728

  Fly   515 EVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEIL 579
            .|.|.|||||.|.::||||||||:|||.||:.|:||||:||||:..|..|:||||||:::|||:|
Human   729 CVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 793

  Fly   580 KEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTK 644
            .:..|..:||||.||||:|||:.|:.||..|:|:|:||||::|:|.||.:||.||:.|::..|.:
Human   794 TDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRR 858

  Fly   645 NPEQRLGCT-GDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTP 708
            |||:|||.: .|..:::|.|||..|.|:.|..|.:.|||.|.:....|.:|||.|||.|.|.|:|
Human   859 NPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSP 923

  Fly   709 IGN-EVVRCINQDEFAGFSFV 728
            ..: ..:....|..|..|.||
Human   924 PRDARPLTAAEQAAFLDFDFV 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	15/71 (21%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	5/58 (9%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	7/53 (13%)
		STKc_nPKC_epsilon	412..729	CDD:270743	164/321 (51%)
PKN1	NP_998725.1	HR1_PKN_1	<52..104	CDD:212012
		HR1_PKN1_2	127..202	CDD:212020
		HR1_PKN1_3	211..284	CDD:212026
		C2_PKN-like	395..482	CDD:176069	15/68 (22%)
		STKc_PKN	621..945	CDD:270741	166/325 (51%)