Protein Alignment Pkc98E and PRKCI

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_002731.4
• Gene: PRKCI / 5584
• HGNCID: 9404
• Length: 596
• Species: Homo sapiens
• Alignment Length: 731
• Identity: 256/731 - (35%)
• Similarity: 360/731 - (49%)
• Gaps: 180/731 - (24%)

  Fly    25 HNLTFGKLAD---EQLIDPYVSIDVDESHFDRATTRPKTFDPVWNEQFVHDVTNVSNINLTVFH- 85
            |.:..|...|   :..:..|...|:..:||:.:.    :|:.:.||  |.|:.:..|..|....
Human    12 HTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSI----SFEGLCNE--VRDMCSFDNEQLFTMKW 70

  Fly    86 -DAALPPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIELKNR-------TDKAKAEA 142
             |....|      |.:|.:  ::.|.|.:...:|.:.:..|||...:..|       .||:
Human    71 IDEEGDP------CTVSSQ--LELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKS---- 123

  Fly   143 VVEHTVAVNKEFKERAGFNRRRGAMR-RRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQ 206
                              ..||||.| |:::..|||.|.|....:...|:.|.:.|||:|:|||:
Human   124 ------------------IYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYK 170

  Fly   207 CQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSL 271
            |..|.|:||||||..|..:|                |:.   :||...|:...:.....||..::
Human   171 CINCKLLVHKKCHKLVTIEC----------------GRH---SLPQEPVMPMDQSSMHSDHAQTV 216

  Fly   272 LYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGE 336
            :                                                ...|...:.|:|.|.|
Human   217 I------------------------------------------------PYNPSSHESLDQVGEE 233

  Fly   337 DNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPG 401
            ..                             :..|..||..|||
Human   234 KE-----------------------------AMNTRESGKASSS--------------------- 248

  Fly   402 KCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANH 466
             ..|.||:.::|:|:||:.||:|...|.||.|||:||:||:.:..|:|:|...|||.:...|:||
Human   249 -LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 312

  Fly   467 PFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYR 531
            |||..|||||||..|||||:||||||||||.:|:.|:.....|.||:||::|||.:||..|:|||
Human   313 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYR 377

  Fly   532 DLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVL 596
            ||||||:|||.|||.||.|:||||||:..|..|:||||||:|||||||:.::||.||||||||||
Human   378 DLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVL 442

  Fly   597 MYEMMAGQPPFE----ADN-----EDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC 652
            |:|||||:.||:    :||     ||.||..|:...:..|..||.:|.|:||.||.|:|::||||
Human   443 MFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGC 507

  Fly   653 ---TGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVV 714
               ||.. :|:.||||..:||..:|::.:.|||:|.:......:|||::||.|...|||..:::|
Human   508 HPQTGFA-DIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIV 571

  Fly   715 RCINQDEFAGFSFVNP 730
            |.|:|.||.||.::||
Human   572 RKIDQSEFEGFEYINP 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	24/113 (21%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	25/58 (43%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	5/53 (9%)
		STKc_nPKC_epsilon	412..729	CDD:270743	176/328 (54%)
PRKCI	NP_002731.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		3/10 (30%)
		Regulatory domain	2..253		76/394 (19%)
		Required for interaction with RAB2	2..28		3/15 (20%)
		PB1_aPKC	26..108	CDD:99725	21/95 (22%)
		Interaction with PARD6A	72..91		6/26 (23%)
		Pseudosubstrate. /evidence=ECO:0000250	125..134		5/8 (63%)
		C1_aPKC	139..193	CDD:410344	26/69 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..246		8/54 (15%)
		STKc_aPKC_iota	233..596	CDD:270769	188/407 (46%)