DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc98E and PRKCH

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_006246.2	Gene:	PRKCH / 5583	HGNCID:	9403	Length:	683	Species:	Homo sapiens

Alignment Length:	740	Identity:	389/740 - (52%)
Similarity:	503/740 - (67%)	Gaps:	71/740 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWN 66
            |.|.|::::.||.||:||.:..||:| |.|  ..||:|||:::.||:....:.:|:.||..|.:|
Human     8 FNGYLRVRIGEAVGLQPTRWSLRHSL-FKK--GHQLLDPYLTVSVDQVRVGQTSTKQKTNKPTYN 69

  Fly    67 EQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDL---WVNLEPQGKIHVI 128
            |:|..:||:..::.|.|||:..|..|.|||||.:.|::|::: |...|.   ||:|||:||:.|:
Human    70 EEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRT-TGASDTFEGWVDLEPEGKVFVV 133

  Fly   129 IELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRR-GAMRRRVHQVNGHKFMATFLRQPTFCSH 192
            |.|..        :..|.|:..::.||.   |.|:| .||||||||:||||||||:|||||:|||
Human   134 ITLTG--------SFTEATLQRDRIFKH---FTRKRQRAMRRRVHQINGHKFMATYLRQPTYCSH 187

  Fly   193 CREFIWGI-GKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVV 256
            |||||||: |||||||||||.||||:||..:|:.|....:..  ||:...|.|||.:|:||:|.:
Human   188 CREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNIN--KVDSKIAEQRFGINIPHKFSI 250

  Fly   257 HSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK 321
            |:||..||||||||||:|:::|||||:.|.||||.|||.|||..||:|..::|:.|:.:|:.|..
Human   251 HNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPGN 315

  Fly   322 QQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAV 386
            ..|                                     ...|.:.:|....|..||.
Human   316 ISP-------------------------------------TSKLVSRSTLRRQGKESSK------ 337

  Fly   387 TGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVD 451
             ...|:|.....|.|   :.:|.||:|||||||||||||..|.|.::||:||||||.|:|||||:
Human   338 -EGNGIGVNSSNRLG---IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVE 398

  Fly   452 CTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEV 516
            |||||||||:||.||||||.|..|||||||||||||:||||||||.|||:|||:.:||.|||||:
Human   399 CTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEI 463

  Fly   517 TLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKE 581
            ..||.|||..|:|||||||||:|||.||||||||||||||||.||:.|.||||||||||||||:|
Human   464 ISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 528

  Fly   582 QEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNP 646
            ..||.:|||||:|||:|||:.|..||||:|||:||::|::|:|:||.||..:|..|||.|:||||
Human   529 MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNP 593

  Fly   647 EQRLG--CTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPI 709
            ..|||  ..|.|:.|.:||||.::||.:|..|.|:|||||::|:..|.:|||.:|.||:||||||
Human   594 TMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPI 658

  Fly   710 GNEVVRCINQDEFAGFSFVNPKFGP 734
            ....:..||||||..||:|:|:..|
Human   659 DEGHLPMINQDEFRNFSYVSPELQP 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	55/134 (41%)
		C1_1	177..228	CDD:278556	40/51 (78%)
		C1_1	252..304	CDD:278556	34/51 (67%)
		STKc_nPKC_epsilon	412..729	CDD:270743	214/318 (67%)
PRKCH	NP_006246.2	C2_PKC_epsilon	8..140	CDD:175981	55/143 (38%)
		C1_1	172..225	CDD:278556	40/52 (77%)
		C1_1	246..298	CDD:278556	34/51 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..342		5/28 (18%)
		S_TKc	355..614	CDD:214567	183/258 (71%)
		STKc_nPKC_eta	359..681	CDD:270742	216/321 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6933
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	874	1.000	Inparanoid score	I414
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		otm40481
orthoMCL	1	0.900	-	-		OOG6_102972
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.860