Protein Alignment Pkc98E and PRKCH

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: XP_047287541.1
• Gene: PRKCH / 5583
• HGNCID: 9403
• Length: 782
• Species: Homo sapiens
• Alignment Length: 838
• Identity: 391/838 - (46%)
• Similarity: 505/838 - (60%)
• Gaps: 168/838 - (20%)

  Fly     2 FTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWN 66
            |.|.|::::.||.||:||.:..||:| |.|  ..||:|||:::.||:....:.:|:.||..|.:|
Human     8 FNGYLRVRIGEAVGLQPTRWSLRHSL-FKK--GHQLLDPYLTVSVDQVRVGQTSTKQKTNKPTYN 69

  Fly    67 EQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQS----------------------- 108
            |:|..:||:..::.|.|||:..|..|.|||||.:.|::|:::
Human    70 EEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFEGWVSSGDPFPLCPPN 134

  Fly   109 ---------------------------------------ETAV---------------------- 112
                                                   .|||
Human   135 PRSPYVFQNSPGSRFPIALWLREFPPDFGLRPRGRGTGDATAVGVCRRRCVSRKPAWTRSPFRTA 199

  Fly   113 -----------------QDLWVNLEPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGF 160
                             ..|||:|||:||:.|:|.|..        :..|.|:..::.||.   |
Human   200 AWPNGKSGRGPGRSPFPPSLWVDLEPEGKVFVVITLTG--------SFTEATLQRDRIFKH---F 253

  Fly   161 NRRR-GAMRRRVHQVNGHKFMATFLRQPTFCSHCREFIWGI-GKQGYQCQVCTLVVHKKCHLSVV 223
            .|:| .||||||||:||||||||:|||||:||||||||||: |||||||||||.||||:||..:|
Human   254 TRKRQRAMRRRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIV 318

  Fly   224 SKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMN 288
            :.|....:..  ||:...|.|||.:|:||:|.:|:||..||||||||||:|:::|||||:.|.||
Human   319 TACTCQNNIN--KVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMN 381

  Fly   289 VHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQ 353
            ||.|||.|||..||:|..::|:.|:.:|:.|....|
Human   382 VHIRCQANVAPNCGVNAVELAKTLAGMGLQPGNISP----------------------------- 417

  Fly   354 SFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGS 418
                    ...|.:.:|....|..||.       ...|:|.....|.|   :.:|.||:||||||
Human   418 --------TSKLVSRSTLRRQGKESSK-------EGNGIGVNSSNRLG---IDNFEFIRVLGKGS 464

  Fly   419 FGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLF 483
            |||||||..|.|.::||:||||||.|:|||||:|||||||||:||.||||||.|..|||||||||
Human   465 FGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLF 529

  Fly   484 FVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKL 548
            ||||:||||||||.|||:|||:.:||.|||||:..||.|||..|:|||||||||:|||.||||||
Human   530 FVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKL 594

  Fly   549 ADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNED 613
            ||||||||||.||:.|.||||||||||||||:|..||.:|||||:|||:|||:.|..||||:|||
Human   595 ADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENED 659

  Fly   614 ELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLG--CTGDENEIRKHPFFAKLDWKELEKR 676
            :||::|::|:|:||.||..:|..|||.|:||||..|||  ..|.|:.|.:||||.::||.:|..|
Human   660 DLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHR 724

  Fly   677 NIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKFGP 734
            .|:|||||::|:..|.:|||.:|.||:||||||....:..||||||..||:|:|:..|
Human   725 QIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQP 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	57/232 (25%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	45/59 (76%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	35/53 (66%)
		STKc_nPKC_epsilon	412..729	CDD:270743	214/318 (67%)
PRKCH	XP_047287541.1	C2_PKC_epsilon	8..122	CDD:175981	43/116 (37%)
		C1_nPKC_epsilon-like_rpt1	265..325	CDD:410385	45/59 (76%)
		C1_nPKC_epsilon-like_rpt2	343..397	CDD:410388	35/53 (66%)
		STKc_nPKC_eta	458..780	CDD:270742	216/321 (67%)