DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and PRKCG

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001303258.1	Gene:	PRKCG / 5582	HGNCID:	9402	Length:	710	Species:	Homo sapiens

Alignment Length:	687	Identity:	306/687 - (44%)
Similarity:	391/687 - (56%)	Gaps:	144/687 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 RRGAMRRR-VHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKC 226
            |:||:|:: ||:|..|||.|.|.:||||||||.:|||||||||.|||||:.|||::||..|..:|
Human    21 RKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFEC 85

  Fly   227 PGMRDEQPAKVEMVPAGQRFNVNLP---HRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMN 288
            ||             ||:....:.|   |:|.:|||...|||||||||||||:.||::|..|.||
Human    86 PG-------------AGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMN 137

  Fly   289 VHKRCQKNVANTCGIN------------------------------------------------- 304
            ||:||.::|.:.||::
Human   138 VHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIP 202

  Fly   305 -----TKQMAEILSS-----------LGISPDKQQPRRS-------------------------- 327
                 |||....:.:           ..:.|...:.|.|
Human   203 DPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELL 267

  Fly   328 --------KYLNQQGGEDNYGASLGADGDGAP-GQSFRSCALSVD-----SLATSTTTMTSGYNS 378
                    |.|||:.|| .|...: ||.|... .|.|.:|...::     .:..|::.:.|...|
Human   268 KAPVDGWYKLLNQEEGE-YYNVPV-ADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPS 330

  Fly   379 SSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDA 443
            .:.......|:.         ||:..:.||:|:.||||||||||||||::|:||:||||:||||.
Human   331 PTDPKRCFFGAS---------PGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDV 386

  Fly   444 IIQDDDVDCTMTEKRILALAANHP-----FLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARR 503
            |:||||||||:.|||:|||....|     |||.|||.|||||||:||||||.|||||:.||:..:
Human   387 IVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGK 451

  Fly   504 FEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFC 568
            |:...|||||||:.:.|.|||..|:|||||||||::||.|||.|:.|||||||.:..|..|.|||
Human   452 FKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFC 516

  Fly   569 GTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSRE 633
            ||||||||||:..|.||.|||||:.|||:|||:||||||:.::|:|||.:||...|.||..||||
Human   517 GTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSRE 581

  Fly   634 AVSILKGFLTKNPEQRLGCTGD-ENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNP--RDANNF 695
            ||:|.||||||:|.:|||...| |..||.|.||..:||:.||:..|.|||||:   |  |...||
Human   582 AVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPR---PCGRSGENF 643

  Fly   696 DAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKF 732
            |..||:..|.|||....|:..|:|.:|.||::|||.|
Human   644 DKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDF 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556	34/50 (68%)
		C1_1	252..304	CDD:278556	31/51 (61%)
		STKc_nPKC_epsilon	412..729	CDD:270743	197/324 (61%)
PRKCG	NP_001303258.1	C1_1	36..88	CDD:278556	36/64 (56%)
		C1_1	101..153	CDD:278556	31/51 (61%)
		C2_PKC_alpha_gamma	158..289	CDD:175992	13/131 (10%)
		S_TKc	351..614	CDD:214567	170/262 (65%)
		STKc_cPKC	354..677	CDD:270739	197/325 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51944
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920