Protein Alignment Pkc98E and PRKCE

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_005391.1
• Gene: PRKCE / 5581
• HGNCID: 9401
• Length: 737
• Species: Homo sapiens
• Alignment Length: 758
• Identity: 437/758 - (57%)
• Similarity: 551/758 - (72%)
• Gaps: 49/758 - (6%)

  Fly     1 MFTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVW 65
            :|.|.|:||:|||..|:||.:..||  ..|......|:|||::::||:|...:..|:.||..|.|
Human     3 VFNGLLKIKICEAVSLKPTAWSLRH--AVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAW 65

  Fly    66 NEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIE 130
            :::||.||.|...|.|.|||||.:..|||||||.|.||:|:|:.:...:.|::|||:|:::|||:
Human    66 HDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIID 130

  Fly   131 LKNRTDKAKAEAVVEHTVAVNKE--FKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHC 193
            |...:.:|..:         |:|  |:||....:|:||:|||||||||||||||:|||||:||||
Human   131 LSGSSGEAPKD---------NEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHC 186

  Fly   194 REFIWG-IGKQGYQCQVCTLVVHKKCHLSVVSKCPGM-RDEQPAKVEMVPAGQRFNVNLPHRFVV 256
            |:|||| ||||||||||||.||||:||..:::||.|: :.|.|.:|    ..|||:||:||:|.:
Human   187 RDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQV----GSQRFSVNMPHKFGI 247

  Fly   257 HSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK 321
            |:||..||||||||||:||::|||||:.|.||||:||:.|||..||::.:.:|::|:.||::|||
Human   248 HNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDK 312

  Fly   322 ---QQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRS-------CALSVDSLATSTTTMTSGY 376
               ...||.|.:  .|.|....||     ..:|.:..||       |...:..|..:.....|..
Human   313 ITNSGQRRKKLI--AGAESPQPAS-----GSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFD 370

  Fly   377 NSSSCMSLAVTGSGGV---GATGETRPGKCSLL---DFNFIKVLGKGSFGKVMLAEKKGTDEIYA 435
            |.......|.:..|.:   |..||.|.|:...|   :|||||||||||||||||||.||.||:||
Human   371 NRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYA 435

  Fly   436 IKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQK 500
            :||||||.|:||||||||||||||||||..||:||.|:.||||.||||||||||||||||||||:
Human   436 VKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQR 500

  Fly   501 ARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTT 565
            :|:|:..|:.|||||||.||.|||.||||||||||||||||.||||||||||||||||:||:.||
Human   501 SRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTT 565

  Fly   566 TFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWL 630
            ||||||||||||||:|.|||.|||||||||||||||||||||||||||:||:||:||||||||||
Human   566 TFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWL 630

  Fly   631 SREAVSILKGFLTKNPEQRLGCTGDEN---EIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDA 692
            |:|||||||.|:||||.:||||...:|   .|::||||.::||..||::.|||||:|::|..||.
Human   631 SKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDV 695

  Fly   693 NNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKFGPE 735
            ||||.:||:|:||||.:...:|:.|||:||.|||:    ||.:
Human   696 NNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSY----FGED 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	59/132 (45%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	47/60 (78%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	35/53 (66%)
		STKc_nPKC_epsilon	412..729	CDD:270743	241/319 (76%)
PRKCE	NP_005391.1	C2_PKC_epsilon	3..135	CDD:175981	59/133 (44%)
		C1_nPKC_epsilon-like_rpt1	161..224	CDD:410385	50/62 (81%)
		Interaction with actin. /evidence=ECO:0000250	223..228		0/4 (0%)
		C1_nPKC_epsilon-like_rpt2	241..295	CDD:410388	35/53 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..356		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..398		7/27 (26%)
		STKc_nPKC_epsilon	412..732	CDD:270743	241/323 (75%)